Siderophores: Amazing Metabolites of Microorganisms

Řezanka, Tomáš; Palyzová, Andrea; Faltýsková, Helena; Sigler, Karel

doi:10.1016/b978-0-444-64181-6.00005-x

Cited by 12 publications

(3 citation statements)

References 101 publications

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“…In natural environments, DFOB concentration ranges from nanomolar to micromolar in soil porewater, − and U(VI) concentration is usually in the range of tens of nanomolar . Although the DFOB and U(VI) concentrations used in this study (1 and 0.5 mM, respectively) are higher, it is the ratio of DFOB relative to U(VI) that determines their complexation and reduction.…”

Section: Environmental Implicationsmentioning

confidence: 92%

“…Siderophores are common organic chelators in the environment and affect metal mobility and bioavailability. , Microorganisms and plants produce siderophores in response to Fe limitation . Their concentration ranges from nanomolar to micromolar in soil pore water and lakes. − They can form stable complexes with Fe(III) and other metal cations . Synthetic siderophore-like metal chelators also complex with uranium, suggesting that the ligands present in siderophores affect uranium speciation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Siderophore DFOB on U(VI) Adsorption to Clay Mineral and Its Subsequent Reduction by an Iron-Reducing Bacterium

Zhang

Dong

et al. 2022

Environ. Sci. Technol.

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Uranium mining and nuclear fuel production have led to significant U contamination. Past studies have focused on the bioreduction of soluble U(VI) to insoluble U(IV) as a remediation method. However, U(IV) is susceptible to reoxidation and remobilization when conditions change.Here, we demonstrate that a combination of adsorption and bioreduction of U(VI) in the presence of an organic ligand (siderophore desferrioxamine B, DFOB) and the Fe-rich clay mineral nontronite partially alleviated this problem. DFOB greatly facilitated U(VI) adsorption into the interlayer of nontronite as a stable U(VI)−DFOB complex. This complex was likely reduced by bioreduction intermediates such as the Fe(II)−DFOB complex and/or through electron transfer within a ternary Fe(II)−DFOB−U(VI) complex. Bioreduction with DFOB alone resulted in a mobile aqueous U(IV)−DFOB complex, but in the presence of both DFOB and nontronite U(IV) was sequestered into a solid. These results provide novel insights into the mechanisms of U(VI) bioreduction and the stability of U and have important implications for understanding U biogeochemistry in the environment and for developing a sustainable U remediation approach.

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Section: Environmental Implicationsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of Siderophore DFOB on U(VI) Adsorption to Clay Mineral and Its Subsequent Reduction by an Iron-Reducing Bacterium

Zhang

Dong

et al. 2022

Environ. Sci. Technol.

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“…The diverse nature of siderophores and their structural as well as functional elements provide access towards many applications, as has been extensively reviewed (Saha et al 2016;Su et al 2018;Albelda-Berenguer et al 2019;Řezanka et al 2019;Hofmann et al 2020) and will not be discussed in detail here. a b c Fig.…”

Section: Nmos Involved In Siderophore Biosynthesismentioning

confidence: 99%

Flavin-dependent N-hydroxylating enzymes: distribution and application

Mügge

Heine

Baraibar

et al. 2020

Appl Microbiol Biotechnol

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Amino groups derived from naturally abundant amino acids or (di)amines can be used as "shuttles" in nature for oxygen transfer to provide intermediates or products comprising NO functional groups such as N-hydroxy, oxazine, isoxazolidine, nitro, nitrone, oxime, C-, S-, or N-nitroso, and azoxy units. To this end, molecular oxygen is activated by flavin, heme, or metal cofactorcontaining enzymes and transferred to initially obtain N-hydroxy compounds, which can be further functionalized. In this review, we focus on flavin-dependent N-hydroxylating enzymes, which play a major role in the production of secondary metabolites, such as siderophores or antimicrobial agents. Flavoprotein monooxygenases of higher organisms (among others, in humans) can interact with nitrogen-bearing secondary metabolites or are relevant with respect to detoxification metabolism and are thus of importance to understand potential medical applications. Many enzymes that catalyze N-hydroxylation reactions have specific substrate scopes and others are rather relaxed. The subsequent conversion towards various NO or N-N comprising molecules is also described. Overall, flavin-dependent N-hydroxylating enzymes can accept amines, diamines, amino acids, amino sugars, and amino aromatic compounds and thus provide access to versatile families of compounds containing the NO motif. Natural roles as well as synthetic applications are highlighted. Key points • NO and N-N comprising natural and (semi)synthetic products are highlighted. • Flavin-based NMOs with respect to mechanism, structure, and phylogeny are reviewed. • Applications in natural product formation and synthetic approaches are provided.

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Potential Application of Siderophores in Biomining: A Brief Review

Horeh,

Sadri

2024

Proceedings of the 63rd Conference of Metallurgists, COM 2024

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Siderophores: Amazing Metabolites of Microorganisms

Cited by 12 publications

References 101 publications

Effect of Siderophore DFOB on U(VI) Adsorption to Clay Mineral and Its Subsequent Reduction by an Iron-Reducing Bacterium

Effect of Siderophore DFOB on U(VI) Adsorption to Clay Mineral and Its Subsequent Reduction by an Iron-Reducing Bacterium

Flavin-dependent N-hydroxylating enzymes: distribution and application

Potential Application of Siderophores in Biomining: A Brief Review

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