In modern number theory there are famous theorems on the modularity of Dirichlet series attached to geometric or arithmetic objects. There is Hecke's converse theorem, Wiles proof of the Taniyama-Shimura conjecture, and Fermat's Last Theorem to name a few. In this article in the spirit of the Langlands philosophy we raise the question on the modularity of the GL 2 -twisted spinor L-function Z G⊗h (s) related to automorphic forms G, h on the symplectic group GSp 2 and GL 2 . This leads to several promising results and finally culminates into a precise very general conjecture. This gives new insights into the Miyawaki conjecture on spinor L-functions of modular forms. We indicate how this topic is related to Ramakrishnan's work on the modularity of the Rankin-Selberg L-series.