Sífilis congénita precoz: A propósito de 2 casos clínicos

S.M, Felipe Cavagnaro; R, Teresita Pereira; P, Carla Pérez; V, Fernanda Vargas Del; C, Carmen Sandoval

doi:10.4067/s0370-41062014000100012

Cited by 7 publications

(10 citation statements)

References 9 publications

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“…In addition, the clinical manifestations of CS may be similar to those occurring in other infectious diseases that affect newborns, such as sepsis and, more rarely, septic shock [29–32]. Given that, we considered that these deaths may have been caused by CS, although it was not stated in the DC [29,30].…”

Section: Discussionmentioning

confidence: 99%

Fetal and infant mortality of congenital syphilis reported to the Health Information System

Canto¹,

Araújo²,

Miranda³

et al. 2019

PLoS ONE

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BackgroundCongenital syphilis (CS) is a major cause of mortality in several countries, especially in Latin America and the Caribbean. This study aimed to analyze fetal and infant mortality of CS reported to the Health Information System in a State in Northeastern Brazil.Methods and resultsThis was a cross-sectional study that analyzed the deaths of CS from 2010 to 2014 through the linkage of the Mortality Information System (SIM) and the Notifiable Diseases Information System (Sinan). The Statistical Package for the Social Sciences (SPSS) version 23.0 was used to calculate the rates of Fetal, Perinatal, Neonatal (early and late), and Postneonatal Mortality. Simple linear regression was performed. Fisher's exact test or Pearson's chi-square test were used for comparison of proportions and Student's t-test was used for comparison of means.Of the 414 cases reported to the SIM as deaths possibly caused by CS, 44 (10.6%) presented CS as the underlying cause. From 2010 to 2014 the Infant Mortality Rate of CS was 16.3 per 100,000 live births (y = 0.65x + 14.33, R2 = 0.2338, p = 0.003). There was an 89.4% underreporting of deaths. Perinatal deaths and fetal deaths of CS accounted for 87.7% and 73.9% of total deaths, respectively.ConclusionsThe results of the study revealed a significant Fetal and Infant Mortality rate of CS and demonstrated the importance of using the linkage method in studies that involve the analysis of secondary data obtained from mortality and disease reporting systems. The underreporting of CS as a cause of fetal and infant mortality leads to unawareness of the reality of deaths from this disease, hindering the development of public policies aimed at its prevention.

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Section: Discussionmentioning

confidence: 99%

Fetal and infant mortality of congenital syphilis reported to the Health Information System

Canto¹,

Araújo²,

Miranda³

et al. 2019

PLoS ONE

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“…All studies that analyzed clinical findings in children with early CS showed some shortcoming in the management of care to the pregnant woman, especially when related to tracking, diagnosing, and providing proper treatment to the mothers as soon as possible (8,28,32) . Researches carried out in Chile, Mexico, and England exposed cases of early CS in which the mothers were only reactive to the second test applied to them or during birth (22)(23)(27)(28)32) . These women may have been infected during pregnancy and present high titer levels at the moment of birth, corresponding to an early stage of the infection.…”

Section: Discussionmentioning

confidence: 99%

Complications, clinical manifestations of congenital syphilis, and aspects related to its prevention: an integrative review

et al. 2021

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Objectives: to identify the scientific evidence about the clinical complications and manifestations of congenital syphilis and aspects related to its prevention. Methods: integrative review after a search in the databases LILACS and MEDLINE, carried out in March 2018, using the descriptors “syphilis, congenital”, “complications”, and “signs and symptoms”, leading to the selection of 27 researches. Results: the publications found were published from 1966 to 2017, and most of them were from Latin America and Africa. Negative outcomes, laboratory changes, and the clinical manifestations in congenital syphilis, whether early or delayed, were, respectively: low weight at birth, anemia, hepatosplenomegaly, and dental alterations. The lack of treatment of the pregnant women in the prenatal was the most common occasion in which the opportunity to prevent the complications of congenital syphilis was lost. Conclusions: the scientific evidences analyzed showed serious complications of congenital syphilis that could be avoided if early opportunities of diagnosing and treating the pregnant women are not lost during the prenatal.

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“…A via de contágio mais importante é a sexual, e deriva de diversas formas clínicas como: sífilis primária, sífilis secundária, sífilis latente precoce e tardia e sífilis terciária. (Cavagnaro et al, 2014). Apresenta cerca de um milhão de casos por ano e é responsável por mais de 300 mil mortes perinatais.…”

Section: Introductionunclassified

“…Estimativas mostram que a doença afeta um milhão de gestantes por ano em todo o mundo, colocando em risco de morte prematura cerca de 200 mil crianças (Rocha et al, 2021). Na América Latina e no Caribe há 3 milhões de casos novos por ano (Cavagnaro et al, 2014). A Organização Mundial de Saúde (OMS) calcula que 12 milhões de pessoas são infectadas a cada ano no mundo e mais de 90% dessas infecções ocorrem em países em desenvolvimento.…”

Section: Introductionunclassified

Identificação de características para diagnóstico da Sífilis e momento correto de intervenção com tratamento

Souza,

Rufino,

Silva

et al. 2023

EACAD

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A sífilis é uma infecção multissistêmica causada pela bactéria Treponema pallidum. Apesar da disponibilidade de estratégias preventivas para a identificação do recém-nascido de risco, e da diminuição global de sua incidência, a sífilis congênita continua a ser um problema significativo tanto nos países em desenvolvimento como nos países desenvolvidos. Embora muitos profissionais da saúde, em países desenvolvidos estejam cientes das características dentárias da sífilis congênita, a maioria nunca viu um caso ou fez o diagnóstico, com isso o objetivo desse estudo é demonstrar aos profissionais de saúde a importância de compreender a sífilis, para que possam identificar os comportamentos de risco e as oportunidades de intervenção, e assim promover intervenções educativas e identificar o diagnóstico precoce da sífilis/sífilis congênita, apresentando características e alterações da sífilis congênita precoce e sífilis congênita tardia, assim como seu diagnóstico e tratamento. Através desse estudo é possível demonstrar aos profissionais de saúde a importância de compreender a sífilis, auxiliando na identificação da doença e dos comportamentos de risco e as oportunidades de intervenção.

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Sífilis congénita precoz: A propósito de 2 casos clínicos

Abstract: CS has significant diagnostic challenges as there is no test for early confirmation, therefore, a high index of suspicion might be key in the treatment and consequent prognosis. Due to the current epidemiology of the condition, it is also important to focus on preventive measures.

Cited by 7 publications

References 9 publications

Fetal and infant mortality of congenital syphilis reported to the Health Information System

Fetal and infant mortality of congenital syphilis reported to the Health Information System

Complications, clinical manifestations of congenital syphilis, and aspects related to its prevention: an integrative review

Identificação de características para diagnóstico da Sífilis e momento correto de intervenção com tratamento

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