Sigmoid colon carcinoma with focal neuroendocrine differentiation associated with ulcerative colitis: A case report

Rifu, Kazuma; Koinuma, Koji; Horie, Hisanaga; Morimoto, Mitsuaki; Kono, Yoshiaki; Tahara, Makiko; Sakuma, Yoshiki; Hosoya, Yoshinori; Kitayama, Joji; Lefor, Alan Kawarai; Sata, Naohiro; Suzuki, Takahiro; Fukushima, Noriyoshi

doi:10.1016/j.ijscr.2016.04.035

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…Histologically, the cells of these tumors are small (100-250nm), polymorphic presenting multiform neurosecretory granules in their cytoplasm 8,11 . Immunohistochemistry is usually positive for neuron specific enolase, keratin and chromogranin A [10,[17][18][19]. The histopathology and immunohistochemistry in the present case was typical of small cell undifferentiated neuroendocrine carcinoma.…”

Section: Discussionmentioning

confidence: 76%

“…Various chemotherapy regimens have been proposed, but without unanimous acceptance 16 . The prevalent pattern is considered to be the one that is used in small-cell lung carcinoma 11 , which combines cisplatin, etoposide and accordingly 5-FU and irinotecan 3,5,16,18,19 . Many authors, based on the affinity of these tumors with carcinoids, propose the use of interferon-a, which stimulates the activity of Natural Killer cells, and reduces the possible hormonal secretion of these tumors 16,18 .…”

Section: Discussionmentioning

confidence: 99%

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Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon

Ioannidis¹,

Chatzidelios²,

Mantzoros³

et al. 2019

CIRUE

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Neuroendocrine carcinoma (NEC) of the colon is a rare and very aggressive tumor with poor prognosis. The current case report presents a 53-year-old male with a 6 cm × 10 cm ascending colon carcinoma, causing large intestine obstruction, with simultaneous multiple hepatic metastases and peritoneal carcinomatosis. Surgical resection of the primary tumor was performed, because of the bowel obstruction, to ameliorate the symptoms before the onset of chemotherapy. Histopathology revealed that the tumor was a small-cell undifferentiated NEC. During the post0operative period, the patient presented pulmonary metastases, and on the 36th post-operative day, death occurred due to respiratory failure.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon

Ioannidis¹,

Chatzidelios²,

Mantzoros³

et al. 2019

CIRUE

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“…1 Colorectal malignancy associated with UC is typically adenocarcinoma, but a small number of cases have reported an association between UC and NEC in the English literature, and their clinicopathological features are summarized in Table 1. [2][3][4][5][6][7][8][9][10][11][12] Unlike NEC, the incidence of neuroendocrine tumor (carcinoid) arising in UC patients is not uncommon (about 10% 13 ).…”

Section: Discussionmentioning

confidence: 99%

A case of rectal neuroendocrine carcinoma in a patient with long‐standing ulcerative colitis involving alterations of the p16‐Rb pathway

Norose

Ohike

Imai

et al. 2017

Pathology International

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The patient was a 54-year-old male who had been suffering from extensive ulcerative colitis (UC) for 17 years. Colonoscopy revealed an elevated lesion in the affected rectum, and its biopsy demonstrated neuroendocrine carcinoma (NEC). The surgical specimen obtained on laparoscopic high anterior resection showed extensive active inflammatory and dysplastic lesions and three grossly visible multifocal malignant lesions: a polypoid fungating tumor of NEC (type 1, 20 mm in diameter, pT3) that had been preoperatively noticed, a polypoid fungating tumor of adenocarcinoma (type 1, 22 mm, pT2) and a protruded sessile polypoid tumor (0-Is, 5 mm, pTis) of adenocarcinoma. The NEC was adjacently accompanied by dysplasia-carcinoma sequential lesions and showed a diffuse immunohistochemical overexpression of p53 and p16 proteins and the loss of Rb with no abnormal immunohistochemical staining of microsatellite instability markers and no KRAS mutations. Fifteen months later, the patient showed liver metastasis from the NEC component, followed by bone and spinal metastasis; he died 22 months after the initial diagnosis. A rare case of lethal NEC arising from long-standing extensive UC was reported. The NEC appeared to be UC-related, not incidental, and complicated by progression from dysplasia to carcinoma involving alterations of the p16-Rb pathway.

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“…The colorectal neuro-endocrine tumour (NET) including GCCC does not present with any specific symptoms, however maypresent with abdominal pain, large mass, constipation, intestinal obstruction, tenesmus, haematochezia or anal pain, however as other goblet cell carcinomas, GCCCs tumour does not illicit carcinoid syndrome. These tumours can be detected incidentally during routine investigations such as colonoscopy (17,30,31,32).…”

Section: Mcdole Et Al From Washington University Inmentioning

confidence: 99%

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

Abdalla¹,

Khan²,

Shah³

et al. 2020

chr

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Carcinoizii cu celule goblet (GCC) sunt tumori neuroendocrine extrem de rare şi sunt caracterizate prin combinaţia lor unică de două tipuri de celule canceroase -neuroendocrine (carcinoide) şi epiteliale (adenocarcinom). În ciuda faptului că GCC este considerată tumoră neuro-endocrină (NET), nu prezintă sindromul carcinoid ilicit. GCC apare de obicei în anexă şi reprezintă mai puţin de 14% din toate tumorile apendiceale. GCC extraapendiceal primar a fost raportat la stomac, duoden, intestinul subţire, colon şi rect. Lucrarea prezintă un caz rar de GCC a colonului ascendent la un bărbat de 57 de ani.Cuvinte cheie: carcinoid cu celule goblet, tumori neuroendocrine, glandă apocrină, celule care prezintă antigen

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Sigmoid colon carcinoma with focal neuroendocrine differentiation associated with ulcerative colitis: A case report

Cited by 6 publications

References 14 publications

Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon

Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon

A case of rectal neuroendocrine carcinoma in a patient with long‐standing ulcerative colitis involving alterations of the p16‐Rb pathway

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

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