Sigmoid Ischemia and the Inflammatory Response following Endovascular Abdominal Aortic Aneurysm Repair

Abstract

The results suggest that the degree of bowel ischemia, endotoxemia, and cytokine generation following elective infrarenal AAA reconstruction may be reduced if the endovascular technique is used instead of conventional surgery.

Colonic epithelial apoptosis during conventional and endoluminal aortic surgery

“…EVAR results in an IR insult to the hindgut and lower limbs, albeit with a much shorter ischaemia time than that associated with conventional surgery. The absence of apoptosis and delay in systemic IL‐6 increase corroborates the evidence recognizing the protection conferred against intestinal IR injury by endoluminal surgery6–8. Given that EVAR requires a relatively short ischaemic interval during stent deployment, this might have been reflected by a relatively low splanchnic IL‐6 concentration.…”

Efficient Intracellular Delivery of Camptothecin by Silica/Titania Hollow Nanoparticles

“…In particular, tumour necrosis factor (TNF) α, interleukin (IL) 1β and IL‐6 are produced6. Detailed descriptions of these cytokines in the systemic circulation and in the lower extremity after aortic surgery have been published7, 8, but their pattern of intraoperative release from the colon remains unclear.…”

Interplay between Coagulation and Inflammation in Open and Endovascular Abdominal Aortic Aneurysm Repair — Impact of Intra-Aneurysmal Thrombus

“…Ischemia and reperfusion of the lower part of the body during and after aortic crossclamping and surgical traumaare the likely contributors. An inflammatory response to endovascular aortic aneurysmr epair has been reported, but in some studiestoalesser magnitude than after open surgery (10,11). Limited tissue injury during endovascular repair has been suggested to result in decreased cytokine production compared with open surgery.Controversially asignificant inflammatory response after endovascular AAA repair have also been reported (12).…”