Background: Surgical implant generation network (SIGN) is a USA-based humanitarian organization which invented and provided SIGN solid intramedullary interlocking nail to the low-and middle-income countries (LMICs) in the world including Nepal for free. In a LMIC like Nepal, the necessary implants are not affordable for patients especially in a public hospital setting. The SIGN nail is actually designed for tibia, but for our patients, we have been using the same nail for the femur too -both antegrade and retrograde. In this study, we analyzed cases of diaphyseal femur fracture treated primarily with SIGN nails. We studied about the union rate, time taken for union, and the rate of complications including function from the SIGN database. Method: After the permission from the SIGN office and Ethical Clearance from the institution, we analyzed the cases from our database. A total of 106 cases of femur fracture fixed with SIGN nail were found in our database. Of 106 cases, 63 cases met the inclusion criteria. The data were entered into SPSS 16, and the results were obtained after analyzing the data. Results: Of 63, 61 (96.83%) fracture united. The average time of union of femur fractures in this study was 13.34 weeks. We encountered 2 (3.17%) cases of nonunion. There were 3 (4.76%) cases with minor complications, and 1 (1.59%) patient with non-union was due to deep infection. Conclusion: SIGN nail provides an acceptable union rate in diaphyseal femur fracture fixation with a low rate of complications.