Smart signage moves beyond traditional signage as it combines digital displays with Artificial Intelligence processes, Machine Learning attributes, and the use of Internet of Things consumer data. This chapter develops a conceptual model that illustrates both the dynamic nature of smart signs in retail contexts and the factors that coexist when consumers interact with this novel marketing communication tool. A set of new concepts and relationships are included in the model to reflect how smart signs two-way communication interface, technological characteristics, effects of psychological mechanism and privacy concerns, and formation of consumer-product relationships, all of which are useful in understanding smart signage persuasion effects. We foresee a fruitful avenue for research in the domain of smart signage and we discuss several implications for retail marketing, consumer wellbeing, and shopping experiences.