Adjacent closely spaced intersections with characteristics of short link distance and high pedestrian flow are primarily located in high-density urban areas. To address the problems of queue overflow, poor traffic operation, and high pedestrian travel delays, a pedestrian-motor vehicle signal optimization method for adjacent closely spaced intersections was proposed in this paper. First, the traffic flow entering the closely spaced intersections is divided into nonarterial and arterial flow categories to establish a delay model of pedestrian crossing. Then, a pedestrian crossing delay model based on pedestrian demand is constructed according to pedestrian crossing time and a space diagram. An optimization model for pedestrians and vehicles at adjacent closely spaced intersections is established, and an artificial intelligence algorithm is used to optimize this model. Finally, a selected case intersection is optimized. The results show that compared with a traditional single optimization method, vehicle delay decreased about 4%, 13.8%, 17.1%, and 25.9% and total pedestrian delay decreased by 3%, 15%, 25%, and 31%, respectively, for the four proposed scenarios.