Signal amplification strategies in photoelectrochemical sensing of carcinoembryonic antigen

Bao, Chengqi; Deng, Lei; Huang, Feng; Yang, Minghui; Li, Xiaoqing

doi:10.1016/j.bios.2024.116543

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2024.116543

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Signal amplification strategies in photoelectrochemical sensing of carcinoembryonic antigen

Chengqi Bao,

Lei Deng,

Feng Huang

et al.

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Cited by 6 publications

References 203 publications

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Self-powered photoelectrochemical sensor based on molecularly imprinted polymer-coupled CBFO photocathode and Ag2S/SnS2 photoanode for ultrasensitive dimethoate sensing

Chen,

Lan,

Yang

et al. 2025

Analytica Chimica Acta

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Self-powered photoelectrochemical sensor based on molecularly imprinted polymer-coupled CBFO photocathode and Ag2S/SnS2 photoanode for ultrasensitive dimethoate sensing

Chen,

Lan,

Yang

et al. 2025

Analytica Chimica Acta

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Mechanism Exploration of the Photoelectrochemical Immunoassay for the Integration of Radical Generation with Self-Quenching

Wang,

Tang,

Wan

et al. 2024

Anal. Chem.

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Portable Capillary-Microplasma Optical Emission Spectrometer: Gold-Labeled and Silver-Stained Signal Amplification for Carcinoembryonic Antigen Detection

He,

Hu,

Yang

et al. 2024

Anal. Chem.

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Signal amplification techniques based on catalytic silver deposition on immunogold labels have been used for immunoassays. However, conventional instruments often suffer from limitations in point-of-care testing due to their bulky size, high cost, and complex operation. We herein designed an integrated, portable 3D-printed device by integrating capillary liquid electrode glow discharge (CLEGD) with optical emission spectrometer (OES) for the sensitive determination of carcinoembryonic antigen (CEA) in tiny samples. Without the need for additional devices, the sample solution is automatically drawn into the discharge chamber under the action of capillary force and applied high voltage; Ag(I) in the analyte is atomized and excited in the discharge plasma, resulting in Ag atomic emission lines at 328.1 nm. The system enables the detection of 10 1 −10 6 ng mL −1 Ag(I) and further quantification of carcinoembryonic antigen concentration. Under optimized conditions, the compact equipment achieves CEA detection comparable to that of ICP-OES, with a linear range of 1−500 ng mL −1 and a limit of detection as low as 0.9 ng mL −1 .

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Signal amplification strategies in photoelectrochemical sensing of carcinoembryonic antigen

Cited by 6 publications

References 203 publications

Self-powered photoelectrochemical sensor based on molecularly imprinted polymer-coupled CBFO photocathode and Ag2S/SnS2 photoanode for ultrasensitive dimethoate sensing

Self-powered photoelectrochemical sensor based on molecularly imprinted polymer-coupled CBFO photocathode and Ag2S/SnS2 photoanode for ultrasensitive dimethoate sensing

Mechanism Exploration of the Photoelectrochemical Immunoassay for the Integration of Radical Generation with Self-Quenching

Portable Capillary-Microplasma Optical Emission Spectrometer: Gold-Labeled and Silver-Stained Signal Amplification for Carcinoembryonic Antigen Detection

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