Signal detection behavior in humans and rats: a comparison with matched tasks

Bushnell, Philip J.; Benignus, Vernon A.; Case, Martin

doi:10.1016/s0376-6357(03)00146-3

Cited by 38 publications

(32 citation statements)

References 37 publications

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“…This task was selected because of the sensitivity of the task to manipulations of basal forebrain corticopetal cholinergic neurons (e.g., McGaughy et al 1996, 1998) and because of recent reports that demonstrated the translational potential and use of this task in multiple species, including mice (St. Peters et al 2011) and humans (Bushnell et al 2003; Demeter et al 2008; Howe et al 2013). The effects of infusions of orexin A directly into the basal forebrain were examined in a well-trained version of the task and with attentional demands increased by presenting a visual distracter.…”

Section: Introductionmentioning

confidence: 99%

Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

2015

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Rationale Orexins are neuropeptides released in multiple brain regions from neurons that originate within the lateral hypothalamus and contiguous perfornical area. The basal forebrain, a structure implicated in attentional processing, receives orexinergic inputs. Our previous work demonstrated that administration of an orexin-1 receptor antagonist, SB-334867, systemically or via infusion directly into the basal forebrain, can disrupt performance in a task that places explicit demands on attentional processing. Objectives Given that the orexin-1 receptor binds orexin A with high affinity, we tested whether orexin A could enhance attention in rats. Methods Attentional performance was assessed using a task that required discrimination of variable duration visual signals from trials when no signal was presented. We also tested whether infusions of orexin A into the lateral ventricle could attenuate deficits following lesions of medial prefrontal cortical cholinergic projections that arise from the basal forebrain. Results Infusions of orexin A into the basal forebrain attenuated distracter-induced decreases in attentional performance. Orexin A attenuated deficits in lesioned animals when a visual distracter was presented. Conclusion The present results support the view that orexin A can enhance attentional performance via actions in the basal forebrain and may be beneficial for some conditions characterized by attentional dysfunction due to disruption of cortical cholinergic inputs.

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Section: Introductionmentioning

confidence: 99%

Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

2015

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“…Third, manipulations that decrease the activity of corticopetal cholinergic neurons, such as systemic or intrabasalis administration of benzodiazepine receptor agonists (Moore et al 1995) or glutamate receptor antagonists (Fadel et al 2001), decrease signal detection in this task (Holley et al 1995;Turchi and Sarter 2001). Finally, some experiments have provided evidence that this task may be useful for translation to humans (Bushnell et al 2003;Demeter et al 2008). In the present experiment, after reaching stable performance levels in this attention task, rats were given either systemic or intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, prior to task performance.…”

Section: Introductionmentioning

confidence: 99%

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats

2009

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“…It has been very effective in establishing the role of specific transmitter and receptor systems in normal function and in diseases such as Alzheimer’s, schizophrenia, and Parkinson’s disease (see reviews by Fray & Robbins, 1996; Levaux, Potvin, Sepehry, Sablier, Mendrek, & Stip, 2007). Bushnell and colleagues (Bushnell, Benigus, & Case, 2003) examined rat and human performance in a simple sustained attention task similar to the task used here. They found similar performance across the two species, although there was some suggestion that human males were differently affected by trial rate (intertrial interval length) than were the other groups.…”

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confidence: 99%

Rats and humans paying attention: Cross-species task development for translational research.

Demeter¹,

Sarter²,

Lustig³

2008

Neuropsychology

105

164

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Substantial gains have been made on the neurobiology of attention from systems neuroscience work in animal models and human cognitive neuroscience. However, the integration of rodent-based research on the specific neurotransmitter systems that subserve attention with the results from human behavioral and neuroimaging studies has been hampered by the lack of tasks that validly assess attention in both species. To address this issue, an operant sustained attention task that has been extensively used in research on the neurobiology of attention in rats was re-designed and validated for use in humans. Although humans showed better performance overall, the two species showed similar effects of several attention-related variables, including the introduction of distractor-related challenge. This task provides a useful tool for integrative, cross-species research, and may help to determine how specific neurotransmitter systems contribute to the hemodynamic changes observed in human functional neuroimaging experiments.Keywords sustained attention; rat; human; distraction; cross-species Animal models play a critical role in research designed to determine the neuronal bases of cognition and behavior. In particular, animal research provides a degree of experimental control and precision not usually feasible in studies using human subjects, as well as avenues for manipulating and monitoring specific neurotransmitter and receptor systems. Attempts to use evidence from animal-based research to inform the design and interpretation of human studies inherently assume that different species draw on similar cognitive processes to perform tasks that are similar in terms of face validity. However, this assumption has been rarely tested, limiting the potential benefits of direct cross-utilization of evidence. Perhaps as a result, treatment approaches for cognitive disorders that are based on animal research frequently fail to translate into clinical efficacy (e.g., Sarter, 2004Sarter, ,2006. This paper describes a set of studies designed to address this issue by characterizing human performance in a task (McGaughy & Sarter, 1995) that has been extensively used in rat research to determine the role of the cholinergic system in sustained attention and in responding to challenging situations that require the intentional, top-down control of attention (for review see Sarter, Hasselmo, Bruno, & Givens, 2005). Here, we compare rat and human performance patterns on the sustained attention task (SAT) under standard conditions and under distraction * Corresponding author: E-mail: clustig@umich.edu NIH Public Access Author ManuscriptNeuropsychology. Author manuscript; available in PMC 2009 July 2. Published in final edited form as:Neuropsychology. 2008 November ; 22(6): 787-799. doi:10.1037/a0013712. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript (dSAT). Our main focus is on the distraction condition, which in rats has been biologically linked to increased acetylcholine efflux and theoretically linked to an i...

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Signal detection behavior in humans and rats: a comparison with matched tasks

Cited by 38 publications

References 37 publications

Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats

Rats and humans paying attention: Cross-species task development for translational research.

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