De-coring is an essential process in the casting process chain, determining the quality and cost of production. In this study, a coupled multibody system (MBS) and finite element modeling (FEM) technique is presented to study the mechanical loads during the de-coring process. The removal of cast-in sand cores from the inner regions of the cast part by de-coring or knocking out is a complex process with dynamic loads. Currently, the process relies upon empirical knowledge and tests. Inorganic sand cores pose additional challenges in the success of the de-coring process. Increasing complexity in geometry and stringent environmental regulations compel a predictive process in the earlier stages of design. Predicting the process’ success is challenged by the dynamic non-linearities of the system. The dynamic characteristics and the interaction between hammer and casting were studied here for the first time using an industrial-based test rig, and a novel modeling approach was formulated. The results of the developed model are in good compliance with the experiments. The methodology presented in this study can be used to include a varying number of hammers and loads. The proposed approach presents the possibility to discretize the process and qualitatively assess the process parameters for optimization.