Key pecking by 4 pigeons was maintained by a multiple schedule consisting of two variable-interval 60-s schedules wherein each food presentation followed a nonresetting 27-s delay that was either briefly signaled at its outset or completely signaled. Brief-signal duration was adjusted so that response rates maintained by the briefly and completely signaled delays of reinforcement were similar. In general, acute administration of small to intermediate doses (0.3 to 3.0 mg/kg) of cocaine produced either small increases in response rates in both components or no change, and larger doses (5.6 to 13.0 mg/kg) decreased response rates. Chronic (i.e., daily) cocaine administration (10.0 mg/ kg) resulted in tolerance to the rate-decreasing effects in both components. Cocaine's effects were generally similar whether delays were completely or briefly signaled. Discontinuation of cocaine administration and subsequent removal of the delay signals also had similar effects in both components of the multiple schedule. Taken together, these results are consistent with the view that the two types of delay signals were equally effective in maintaining responding during the variableinterval schedules.Key words: signaled delay of reinforcement, conditioned reinforcement, cocaine, tolerance, variableinterval schedule, key peck, pigeonsThe purpose of the present experiment was to study the effects of acute and chronic (i.e., daily) cocaine administration on responding maintained by briefly and completely signaled delays to reinforcement. Key pecking by 4 pigeons was maintained by a multiple schedule consisting of two variableinterval (VI) 60-s components, wherein each reinforcer followed a 27-s delay. In one component the delay was briefly signaled by a change in key color at its beginning; in the other component the delay was completely signaled. Roughly equal response rates were established in the two components of the multiple schedule via manipulation of the brief-signal duration. Cocaine was administered acutely and then chronically to determine whether drug effects on performance would differ for the two types of signaling arrangements.Cocaine was chosen for study in the present experiment because it has been suggested that this drug and other psychomotor stimu-