Aiming at the problem of poor transmission effect and low transmission integrity of multimedia digital real-time signal, this paper studies the optimization, and puts forward a method of multimedia digital real-time signal transmission based on probability and statistics method.Based on the principle of information feature collection, a real-time signal transmission model of multimedia digitization is constructed, and the transmission rate of multimedia digitization real-time signal is effectively controlled according to the collected information, so as to ensure the integrity of signal transmission.Finally, the experiment proves that the multimedia digital real-time signal transmission method based on probability statistics method has high integrity and can better improve the signal transmission effect.