Signal Generation with Gold Nanoparticles: Photophysical Properties for Sensor and Imaging Applications

Wei, Qingshan; Wei, Alexander

doi:10.1002/9780470552704.ch10

Cited by 7 publications

(10 citation statements)

References 255 publications

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“…nm, to the extent that single particle scattering is easily detected by dark-field microscopy [13]. Dark field imaging, is particularly important for vitro cell studies in cancer research as it allows the imaging of live cells and observation of their propagation under different physiological conditions without the addition of dyes of fluorescent labels [20,21].…”

Section: Application Of Gold Nanoparticlesmentioning

confidence: 99%

“…Therefore the dielectric function and can be monitored by tracking shifts in the LSPR [13]. Antibody-functionalised AuNPs have been used to detect proteins in saline, serum and whole blood [31].…”

Section: Figurementioning

confidence: 99%

“…AuNPs, AgNPs and CuNPs possess strong LSPR bands in the visible region, in comparison to other metal nanoparticles that have broad and weak bands in the UV region [4,14]. In some sources, the LSPR is described in terms of extinction efficiency Q ext , which is defined as the ratio of C ext to geometrical cross-section area, πr 2 in the case of spheres [13].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…ACCEPTED MANUSCRIPT 4 dielectric function is negative when ω is below some threshold frequency ω p , known also as the plasma frequency [12] For spherical particles smaller than 20nm, the extinction cross-section C ext particles can be calculated using Mie theory the formulations of which are derived from Maxwell's equations [13]:…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The optical extinction of the smaller nanoparticles is mostly composed of absorption and therefore, they are more beneficial for the use photothermal therapy, as they possess greater efficiently of the conversion to heat for cell and tissue destruction than larger AuNPs [13].…”

Section: Application Of Gold Nanoparticlesmentioning

confidence: 99%

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Section: Application Of Gold Nanoparticlesmentioning

confidence: 99%

Section: Figurementioning

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Section: Accepted Manuscriptmentioning

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Optical Imaging with Dynamic Contrast Agents

Wei

2011

Chemistry A European J

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Biological imaging applications often employ molecular probes or nanoparticles for enhanced contrast. However, resolution and detection are still often limited by the intrinsic heterogeneity of the Isample, which can produce high levels of background that obscure the signals of interest. In this article we describe approaches to overcome this obstacle based on the concept of dynamic contrast, a strategy for elucidating signals by the suppression or removal of background noise. Dynamic contrast mechanisms can greatly reduce the loading requirement of contrast agents, and may be especially useful for single-probe imaging. Dynamic contrast modalities are also platform-independent, and can enhance the performance of sophisticated biomedical imaging systems or simple optical microscopes alike. Dynamic contrast is performed in two stages: i) a signal modulation scheme to introduce time-dependent changes in amplitude or phase, and ii) a demodulation step for signal recovery. Optical signals can be coupled with magnetic nanoparticles, photoswitchable probes, or plasmon-resonant nanostructures for modulation by magnetomotive, photonic, or photothermal mechanisms respectively. With respect to image demodulation, many of the strategies developed for signal processing in electronics and communication technologies can also be applied toward the editing of digital images. The image processing step can be as simple as differential imaging, or may involve multiple reference points for deconvolution using cross-correlation algorithms. Periodic signals are particularly amenable to image demodulation strategies based on Fourier transform; the contrast of the demodulated signal increases with acquisition time, and modulation frequencies in the kHz range are possible. Dynamic contrast is an emerging topic with considerable room for development, both with respect to molecular or nanoscale probes for signal modulation, and also to methods for more efficient image processing and editing.

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Electrical pulse - mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy

Lin

et al. 2012

Laser Phys. Lett.

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Electrical pulse‐mediated enhanced silver nanoparticles delivery is a much better method for intracellular surfaceenhanced Raman spectroscopy (SERS) measurements of suspension cells. Robust and high‐quality SERS spectra of living suspension cells were obtained based on an electroporationSERS method, which can overcomes the shortcoming of nonuniform distribution of silver nanoparticles localized in the cell cytoplasm after electroporation and reduces the amount variance of silver nanoparticles delivered into different cells. The electroporation parameters include three 150 V (375 V/cm) electric pulses of 1, 5, and 5 ms durations respectively. Our results indicate that considerable amount of silver nanoparticles can be rapidly delivered into the human promyelocytic leukemia HL60 cells, and the satisfied SERS spectra were obtained while the viability of the treated cells was highly maintained (91.7%). The electroporation‐SERS method offers great potential approach in delivering silver nanoparticles into living suspension cells, which is useful for widely biomedical applications including the real‐time intracellular SERS analysis of living cells. (© 2012 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA) (© 2011 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA)

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Signal Generation with Gold Nanoparticles: Photophysical Properties for Sensor and Imaging Applications

Cited by 7 publications

References 255 publications

Mycofabrication of common plasmonic colloids, theoretical considerations, mechanism and potential applications

Mycofabrication of common plasmonic colloids, theoretical considerations, mechanism and potential applications

Optical Imaging with Dynamic Contrast Agents

Electrical pulse - mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy

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