Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study

Han, Weiyu; Aitken, Dawn; Zhu, Zhaohua; Halliday, Andrew; Wang, Xia; Antony, Benny; Cicuttini, Flavia Maria; Jones, Graeme; Ding, Changhai

doi:10.1136/annrheumdis-2015-208360

Cited by 81 publications

(99 citation statements)

References 45 publications

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“…As stated before, the infrapatellar or Hoffa's fat pad is currently a topic of avid research with a number of recent publications [3,8,53]. In contrast, the SPFP fat pad has been less well studied, which is why this longitudinal analysis adds important insights into the role of fat pads in knee joint degeneration.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that an increase in signal intensity on fluid-sensitive fat-saturated sequences, representing an increase in tissue fluid referred to as edema, is sensitive in the acute phase of the disease [4,5,45]. More recently, it has been suggested that the infrapatellar fat pad also plays a relevant role in the development of OA [1][2][3]. OA is a disease with multifactorial pathophysiology, including inflammatory processes, modulated by mediators, some of which ultimately accelerate cartilage degeneration [46][47][48][49][50][51][52].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have focused on the infrapatellar or Hoffa's fat pad, considering it to be relevant for the progression of knee osteoarthritis [1][2][3]. It has been suggested to contribute to joint lubrication and to absorb loading forces [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested to contribute to joint lubrication and to absorb loading forces [4][5][6][7]. Associations of infrapatellar fat pad imaging findings and joint degeneration have been inconsistent, with an increase in the volume of Hoffa's fat pad being associated with either accelerated [8] or slowed cartilage degeneration [9], and signal intensity alterations associated with worsening of clinical symptoms and knee OA imaged with MRI [3].…”

Section: Introductionmentioning

confidence: 99%

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Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative

et al. 2017

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Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative. Results Baseline SPFP signal alterations were found in 51% of the subjects (n = 217), of whom 11% (n = 23) additionally had a mass effect. Progression of cartilage lesions was significantly higher in subjects with signal alteration versus without (adjusted mean increases, 95% CI; patella: 0.29, −0.07 to 0.64 vs −0.04, −0.40 to 0.31; p < 0.001; trochlea: 0.47, 0.16 to 0.77 vs 0.31, 0.01 to 0.61; p = 0.007). BML progression was also more likely in subjects with signal alteration (OR 1.75, 95% CI 1.09 to 2.82; p = 0.021). Mass effect was not associated with joint degeneration and SPFP findings were not associated with clinical worsening (p > 0.18 for all). Conclusion Patellofemoral joint degeneration over 48 months was significantly increased in subjects with SPFP signal alteration, suggesting an association between SPFP abnormalities and the progression of patellofemoral OA. Permalink

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative

et al. 2017

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“…The biomarkers of osteoarthritis are I type urinary pyridine (pyridine PYD), the C and N end peptide collagen cross linking peptide (CTX-I) is an indicator of the degree of the osteoarthritis, but detection of PYD and the end need ELISA kit and microplate reader, which price is higher and is not suitable for economic conditions a little worse [10,11]. As a marker of osteoarthritis, serum calcitonin (calcitonin) does not apply to all groups of people, and it is not applicable to some patients.…”

Section: Introductionmentioning

confidence: 99%

Study on the clinical value of miRNA98b as a potential biomarker for osteoarthritis

Wang¹,

Ma²,

Xu³

et al. 2018

biomedicalresearch

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Objective: Osteoarthritis is a serious threat to the health of patients. Biomarkers have important significance in the diagnosis of bone arthritis. Bone mineral density is one of the important indicators for the detection of bone joint inflammation, but its detection is time-consuming and laborious. MicroRNA regulates cancer and inflammation. This study was to investigate the potential value of biomarkers miRNA98b in the diagnosis of early osteoarthritis. Methods: 69 cases of patients with osteoarthritis and 69 cases of healthy volunteers were regarded as research objects. Etidronate disodium had been continuously administrated for 4 w. The patient's bone density reached to the normal value which was regarded as effectiveness of the treatment. The miRNA98b level before and after therapy in blood cells of patients with osteoarthritis and healthy volunteers was detected by real time RT-PCR. The correlation between miRNA98b levels and osteoarthritis was analysed. Results: mRNA level of miRNA98b in blood cells of patients with osteoarthritis was higher than that of healthy volunteers. After being continuously administrated for 2 w, mRNA of miRNA98b in blood cells decreased, there was no significant change in the level of miRNA98b in blood cells of healthy volunteers. The level of miRNA98b in the blood cells of patients with severe osteoarthritis is higher than that in the blood cells of patients with general osteoarthritis, the difference was statistically significant (P<0.05). The level of miRNA98b in the blood cells of patients with osteoarthritis has a positive correlation with the severity of osteoarthritis. Conclusion: MiRNA98b in blood cells of patients with osteoarthritis may be a potential biomarker for osteoarthritis. The level of miRNA98b was correlated with the severity of osteoarthritis.

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Relationship Between Knee Pain and Infrapatellar Fat Pad Morphology: A Within‐ and Between‐Person Analysis From the Osteoarthritis Initiative

Steidle-Kloc

Culvenor

Dörrenberg

et al. 2018

Arthritis Care & Research

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Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study

Abstract: IPFP signal intensity alteration at baseline was associated with knee structural abnormalities and clinical symptoms cross-sectionally and longitudinally in older adults, suggesting that it may serve as an important imaging biomarker in knee OA.

Cited by 81 publications

References 45 publications

Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative

Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative

Study on the clinical value of miRNA98b as a potential biomarker for osteoarthritis

Relationship Between Knee Pain and Infrapatellar Fat Pad Morphology: A Within‐ and Between‐Person Analysis From the Osteoarthritis Initiative

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