Signal-to-noise analysis of biomedical photoacoustic measurements in time and frequency domains

Telenkov, Sergey A.; Mandelis, Andreas

doi:10.1063/1.3505113

Cited by 73 publications

(48 citation statements)

References 17 publications

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“…Also, in this study, we employed an unweighted least-squares data fidelity term, which is equivalent to the maximum likelihood estimator assuming that the randomness in the measured data is due to additive Gaussian white noise (Wernick M. N. & Aarsvold, 2004). However, additive Gaussian white noise may not be a good approximation in practice (Telenkov & Mandelis, 2010). Identification of the noise sources and characterization of their second order statistical properties will facilitate iterative reconstruction algorithms that may optimally reduce noise levels in the reconstructed images.…”

Section: Discussion and Summarymentioning

confidence: 99%

Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography

et al. 2012

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Iterative image reconstruction algorithms for optoacoustic tomography (OAT), also known as photoacoustic tomography, have the ability to improve image quality over analytic algorithms due to their ability to incorporate accurate models of the imaging physics, instrument response, and measurement noise. However, to date, there have been few reported attempts to employ advanced iterative image reconstruction algorithms for improving image quality in three-dimensional (3D) OAT. In this work, we implement and investigate two iterative image reconstruction methods for use with a 3D OAT small animal imager: namely, a penalized least-squares (PLS) method employing a quadratic smoothness penalty and a PLS method employing a total variation norm penalty. The reconstruction algorithms employ accurate models of the ultrasonic transducer impulse responses. Experimental data sets are employed to compare the performances of the iterative reconstruction algorithms to that of a 3D filtered backprojection (FBP) algorithm. By use of quantitative measures of image quality, we demonstrate that the iterative reconstruction algorithms can mitigate image artifacts and preserve spatial resolution more effectively than FBP algorithms. These features suggest that the use of advanced image reconstruction algorithms can improve the effectiveness of 3D OAT while reducing the amount of data required for biomedical applications.

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Section: Discussion and Summarymentioning

confidence: 99%

Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography

et al. 2012

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“…The amplitude of the PA signals from different targets for different modulation frequencies of laser light were obtained by using the cross-correlation operation, also known as matched filtering on the detected ultrasound signal with the reference signal of the intensity-modulated light [27]. Examples of laser-induced tone-burst PA signal from optically absorbant silicone phantom and resulting signals after applying the matched filtering with the reference signal are shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Measuring non-radiative relaxation time of fluorophores with biomedical applications by intensity-modulated laser-induced photoacoustic effect

Soroushian¹,

Yang²

2011

Biomed. Opt. Express

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Modulated tone-burst light was employed to measure non-radiative relaxation time of fluorophores with biomedical importance through photoacoustic effect. Non-radiative relaxation time was estimated through the frequency dependence of photoacoustic signal amplitude. Experiments were performed on solutions of new indocyanine green (IR-820), which is a near infrared dye and has biomedical applications, in two different solvents (water and dimethyl sulfoxide (DMSO)). A 1.5 times slower non-radiative relaxation for the solution of dye in DMSO was observed comparing with the aqueous solution. This result agrees well with general finding that non-radiative relaxation of molecules in triplet state depends on viscosity of solvents in which they are dissolved. Measurements of the non-radiative relaxation time can be used as a new source of contrast mechanism in photoacoustic imaging technique. The proposed method has potential applications such as imaging tissue oxygenation and mapping of other chemophysical differences in microenvironment of exogenous biomarkers.

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“…The safety standard sets the maximum exposure level for λ = 1064 nm and exposure duration t = 10 −7 – 10 s as E MPE = 5.5 t 0.25 (J/cm 2 ) [46], where E stands for laser exposure. If I 0 is defined as laser irradiance (W/cm 2 ), then the maximum duration ( t max ) of I 0 to reach E MPE level can be obtained by t max = (5.5/ I 0 ) 4/3 .…”

Section: Materials and Experimentalmentioning

confidence: 99%

Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics

Alwi¹,

Telenkov²,

Mandelis³

et al. 2012

Biomed. Opt. Express

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116

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In this study, we report for the first time the use of silica-coated superparamagnetic iron oxide nanoparticles (SPION) as contrast agents in biomedical photoacoustic imaging. Using frequency-domain photoacoustic correlation (the photoacoustic radar), we investigated the effects of nanoparticle size, concentration and biological media (e.g. serum, sheep blood) on the photoacoustic response in turbid media. Maximum detection depth and the minimum measurable SPION concentration were determined experimentally. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus and murine quadricept) was evaluated and the strong potential of silica-coated SPION as a possible photoacoustic contrast agents was demonstrated.

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Signal-to-noise analysis of biomedical photoacoustic measurements in time and frequency domains

Cited by 73 publications

References 17 publications

Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography

Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography

Measuring non-radiative relaxation time of fluorophores with biomedical applications by intensity-modulated laser-induced photoacoustic effect

Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics

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