Signal Transduction in Myocardial Hypertrophy and Myosin Expression

Scintigraphic Evidence for a Specific Long-Chain Fatty Acid Transporting System Deficit and the Genetic Background in a Patient With Hypertrophic Cardiomyopathy

“…5, 16 Kusaka and Tanaka et al 19 reported induction of cardiac hypertrophy in rats by inhibition of CD36 molecule by sulfo-N-succinimidyl palmitate. Although the mechanism behind cardiac hypertrophy due to CD36 inhibition in sarcolemma is undetermined, increased carbohydrate utilization in response to reduced utilization of long-chain fatty acids [6][7][8]20 might be related to signal transduction of the myosin heavy chain gene 21,22 and might activate growth factor (TGF-, bFGF) production. 23 Further investigations are, however, necessary to determine the etiological implications of impaired CD36 molecule expression and its genetic deficits in human hypertrophic cardiomyopathy.…”