1995
DOI: 10.1016/0009-2797(95)03642-3
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Signal transduction mechanism in response to aflatoxin B1 exposure: phosphatidylinositol metabolism

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Cited by 13 publications
(2 citation statements)
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“…For example, AFB 1 exposure in rats leads to the stimulation of phosphatidylinositol kinase, which is a key enzyme in cell signalling mechanisms. 34 Such cellular signalling events may influence early stages of hepadnaviral replication. In a recent study, Bruns et al 35 suggested that an enhanced phosphorylation of DHBV core particles may facilitate release of viral genomes from cores, leading to the increase in copy number of cccDNA, which is the matrix of viral replication, and consequently may result in an enhancement of viral replication.…”
Section: Discussionmentioning
confidence: 99%
“…For example, AFB 1 exposure in rats leads to the stimulation of phosphatidylinositol kinase, which is a key enzyme in cell signalling mechanisms. 34 Such cellular signalling events may influence early stages of hepadnaviral replication. In a recent study, Bruns et al 35 suggested that an enhanced phosphorylation of DHBV core particles may facilitate release of viral genomes from cores, leading to the increase in copy number of cccDNA, which is the matrix of viral replication, and consequently may result in an enhancement of viral replication.…”
Section: Discussionmentioning
confidence: 99%
“…The reports showed that AFB 1 might induce mutation of Ki-ras gene in hepatocarcinogenesis and at codon 249 of the p53 tumor suppressor gene (Soman and Wogan, 1993;Nose et al, 1993). It was also reported that AFB 1 might increase phosphatidyl metabolism resulting in an increase in intracellular signal transduction (Mistry et al, 1995). However, the results by Liu et al (2002) showed that aflatoxin did not induce the apoptosis in swine alveolar macrophages.…”
Section: Discussionmentioning
confidence: 99%