Abstract-The explosive growth in mobile Internet and related services has increased the need for more bandwidth in cellular networks. The Long-Term Evolution (LTE) technology is an attractive solution for operators and subscribers to meet such need since it provides high data rates and scalable bandwidth. Radio Resource Management (RRM) is essential for LTE to provide better communication quality and meet the application QoS requirements. Cognitive resource management is a promising solution for LTE RRM as it improves network efficiency by exploiting radio environment information, intelligent optimization algorithms to configure transmission parameters, and mitigate interference. In this paper, we propose a cognitive resource management scheme to adapt LTE network parameters to the environment conditions. The scheme optimizes resource blocks assignment, modulation selection and bandwidth selection to maximize throughput and minimize interference. The scheme uses constrained optimization for throughput maximization and interference control. It is also enhanced by learning mechanism to reduce the optimization complexity and improve the decisionmaking quality. Our evaluation results show that our scheme achieved significant improvements in throughput and LTE system capacity. Results also show the improvement in the user satisfaction over other techniques in LTE RRM.