Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1

Yu, Fang; Lepont, Pierig; Fassett, John; Ford, Stephen P.; Mubaidin, Adnan M. D.; Hamilton, Richard T.; Nilsen-Hamilton, Marit

doi:10.1210/endo.140.11.7142

Cited by 19 publications

(3 citation statements)

References 31 publications

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“…Four distinct PLF genes have been characterized (10,11). Sequence identity of the mRNA products from these genes is greater than 90%, thus RT-PCR followed by diagnostic restriction digestion was used to ascertain the relative abundance of each specific mRNA.…”

Section: Plf Expression During Fibrosarcoma Developmentmentioning

confidence: 99%

“…Expression of PLF in the placenta is developmentally regulated, with hormone production peaking at mid-gestation (8,9). PLF proteins with nearly identical amino acid sequences are encoded by four or more distinct genes, and all of these genes are expressed in the placenta (9)(10)(11). PLF is angiogenic (12) and seems to be important for the migration of uterine vascular endothelial cells toward the giant cells (13), the outer layer of the extraembryonic compartment at the implantation site.…”

mentioning

confidence: 99%

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Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression

Toft

Rosenberg

Bergers

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Proliferin (PLF) is an angiogenic placental hormone. We now report that PLF gene expression can also occur in a progressive fibrosarcoma mouse tumor cell model. PLF mRNA and protein are detectable at very low levels in cell lines derived from the mild noninvasive stage of tumor development. Expression is greatly augmented in cell lines from the aggressively invasive stage of development, a stage at which the tumor becomes highly angiogenic, and PLF expression remains high in cell lines from the end stage of fibrosarcoma. Activator protein 1 factors present at high levels in the more invasive stages of the tumor may in part allow for increased PLF expression, as cells from the mild stage in which c-jun and junB are stably expressed secrete levels of PLF comparable to that of the advanced stages. Secreted PLF protein is functionally important in tumor cell angiogenic activity, as demonstrated by the reduction of angiogenic activity in fibrosarcoma cell culture medium by immunodepletion of PLF. These results suggest that an extraembryonic genetic program, which has evolved to support fetal growth, may be reactivated in certain tumors and contribute to tumor growth.

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Section: Plf Expression During Fibrosarcoma Developmentmentioning

confidence: 99%

mentioning

confidence: 99%

Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression

Toft

Rosenberg

Bergers

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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“…Mitogen-regulated proteins, which are also called proliferins (PLFs), are nonclassical members of the family of prolactin/growth hormones that are expressed at high levels by the placenta during pregnancy [ 21 , 22 ]. The PLF family consists of four homologous members (PLF-related protein and PLF-1, PLF-2, and PLF-3) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Goto

Inoue

Piao

et al. 2021

Stem Cells International

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Background. We recently demonstrated that proliferin-1 (PLF-1) functions as an apoptotic cell-derived growth factor and plays an important role in vascular pathobiology. We therefore investigated its role in muscle regeneration in response to cardiotoxin injury. Methods and Results. To determine the effects of PLF-1 on muscle regeneration, we used a CTX-induced skeletal muscle injury model in 9-week-old male mice that were administered with the recombinant PLF-1 (rPLF-1) or neutralizing PLF-1 antibody. The injured muscles exhibited increased levels of PLF-1 gene expression in a time-dependent manner. On day 14 after injury, rPLF-1 supplementation ameliorated CTX-induced alterations in muscle fiber size, interstitial fibrosis, muscle regeneration capacity, and muscle performance. On day 3 postinjury, rPLF-1 increased the levels of proteins or genes for p-Akt, p-mTOR, p-GSK3α/β, p-Erk1/2, p-p38MAPK, interleukin-10, Pax7, MyoD, and Cyclin B1, and it increased the numbers of CD34+/integrin-α7+ muscle stem cells and proliferating cells in the muscles and/or bone marrow of CTX mice. An enzyme-linked immunosorbent assay revealed that rPLF-1 suppressed the levels of plasma tumor necrosis factor-α and interleukin-1β in CTX mice. PLF-1 blocking accelerated CTX-related muscle damage and dysfunction. In C2C12 myoblasts, rPLF-1 increased the levels of proteins for p-Akt, p-mTOR, p-GSK3α/β, p-Erk1/2, and p-p38MAPK as well as cellular functions; and these effects were diminished by the depletion of PLF-1 or silencing of its mannose-6-phosphate receptor. Conclusions. These findings demonstrated that PLF-1 can improve skeletal muscle repair in response to injury, possibly via the modulation of inflammation and proliferation and regeneration, suggesting a novel therapeutic strategy for the management of skeletal muscle diseases.

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Do molecular signals from the conceptus influence endometrium decidualization in rodents?

Herington

Bany

2009

J Exp Zool Pt B

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A critical period in establishing pregnancy occurs after the onset of implantation but before placental development. Evidence strongly suggests that abnormalities occurring during this period can result in pregnancy termination or in pre-eclampsia; the latter may lead to small-for-gestational-weight offspring that are likely to be unhealthy. Clearly, events occurring in the endometrium during the implantation process are crucial for proper fetal development and for optimal offspring health. In several mammalian species bi-directional communication between the conceptus and endometrium during implantation is required for successful pregnancy. Although different implantation and placentation modes occur in different mammalian species, common aspects of this bi-directional signaling may exist. The molecular signals from the trophoblast cells of the conceptus, which direct endometrial changes during implantation progression, are well known in some non-rodent species. Currently, we know little about such signaling in rodents during implantation progression, when the endometrium undergoes decidualization. This review focuses on data that support the hypothesis that paracrine signals from the rodent conceptus influence decidualization. Where possible, these findings are compared and contrasted to information currently known in other species that exhibit different implantation modes.

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Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1

Cited by 19 publications

References 31 publications

Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression

Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Do molecular signals from the conceptus influence endometrium decidualization in rodents?

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