Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression

Taheri, Mojtaba; Tehrani, Hossein Abdul; Dehghani, Sadegh; Rajabzadeh, Alireza; Alibolandi, Mona; Zamani, Nina; Arefian, Ehsan; Ramezani, Mohammad

doi:10.1016/j.cytogfr.2024.01.004

Cited by 5 publications

(1 citation statement)

References 200 publications

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“…While opinions diverge regarding the influence of MSCs on malignant tumors—with some studies suggesting a substantial promotive effect and others indicating the contrary—this discrepancy may stem from differences in the sources of MSCs used in research or the specific components of MSCs being examined for their effects on tumors. 289 , 290 , 291 Nonetheless, it is evident that a greater number of reports support the notion that MSCs facilitate the development of various malignancies. Moreover, extensive research has revealed that MSCs contribute to a complex array of interactions within the TME, leading to tumor cell survival, proliferation, migration, and ultimately, metastasis, and deterioration.…”

Section: Discussionmentioning

confidence: 99%

The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics

Tang,

Chen,

Wang

et al. 2024

MedComm

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Mesenchymal stem cells (MSCs) are recruited by malignant tumor cells to the tumor microenvironment (TME) and play a crucial role in the initiation and progression of malignant tumors. This role encompasses immune evasion, promotion of angiogenesis, stimulation of cancer cell proliferation, correlation with cancer stem cells, multilineage differentiation within the TME, and development of treatment resistance. Simultaneously, extensive research is exploring the homing effect of MSCs and MSC‐derived extracellular vesicles (MSCs‐EVs) in tumors, aiming to design them as carriers for antitumor substances. These substances are targeted to deliver antitumor drugs to enhance drug efficacy while reducing drug toxicity. This paper provides a review of the supportive role of MSCs in tumor progression and the associated molecular mechanisms. Additionally, we summarize the latest therapeutic strategies involving engineered MSCs and MSCs‐EVs in cancer treatment, including their utilization as carriers for gene therapeutic agents, chemotherapeutics, and oncolytic viruses. We also discuss the distribution and clearance of MSCs and MSCs‐EVs upon entry into the body to elucidate the potential of targeted therapies based on MSCs and MSCs‐EVs in cancer treatment, along with the challenges they face.

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Section: Discussionmentioning

confidence: 99%

The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics

Tang,

Chen,

Wang

et al. 2024

MedComm

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Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE

Pi,

Zuo,

Wang

et al. 2024

International Immunopharmacology

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Mesenchymal Stem Cell Membrane‐Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal–Organic Framework Nanoparticles

Tong,

Gao,

Luo

2024

IET Nanobiotechnology

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Mesenchymal stem cell (MSC) membrane‐coated metal–organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper‐based MOFs (Cu‐MOFs) in tumor cells. By leveraging the natural homing abilities and biocompatibility of MSC membranes, Cu‐MOFs can be effectively targeted to tumor sites, promoting increased cellular uptake. This coating not only facilitates superior internalization by cancer cells but also augments the therapeutic outcomes due to the enhanced delivery of copper ions. In vitro studies demonstrate that MSC membrane‐coated Cu‐MOFs (MSC‐Cu‐MOFs) significantly improve the cytotoxic effects on tumor cells compared to uncoated Cu‐MOFs. This novel strategy presents a promising avenue for advancing the precision and effectiveness of cancer treatment modalities, showcasing potential for clinical applications in oncology.

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Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression

Cited by 5 publications

References 200 publications

The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics

The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics

Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE

Mesenchymal Stem Cell Membrane‐Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal–Organic Framework Nanoparticles

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