Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells

Falank, Carolyne; Fairfield, Heather; Reagan, Michaela R.

doi:10.3389/fendo.2016.00067

Cited by 73 publications

(75 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Decreasing MAT may result in stronger bones, while strengthening bones may result in decreased MAT through feedback systems that may prove to be beneficial when targeting the microenvironment for MM and other tumor cells within the BM. More on the specifics of MAT-MM interactions can be found in our recent publication on this topic [84]. …”

Section: Myeloma Interaction With Bm Elementsmentioning

confidence: 99%

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

et al. 2016

Self Cite

View full text Add to dashboard Cite

Researchers globally are working towards finding a cure for multiple myeloma (MM), a destructive blood cancer diagnosed yearly in ~750,000 people worldwide [1]. Although MM targets multiple organ systems, it is the devastating skeletal destruction experienced by over 90% of patients that often most severely impacts patient morbidity, pain, and quality of life. Preventing bone disease is therefore a priority in MM treatment, and understanding how and why myeloma cells target the bone marrow (BM) is fundamental to this process. This review focuses on a key area of MM research: the contributions of the bone microenvironment to disease origins, progression, and drug resistance. We describe some of the key cell types in the BM niche: osteoclasts, osteoblasts, osteocytes, adipocytes and mesenchymal stem cells. We then focus on how these key cellular players are, or could be, regulating a range of disease-related processes spanning MM growth, drug resistance, and bone disease (including osteolysis, fracture, and hypercalcemia). We summarize the literature regarding MM-bone cell and MM-adipocyte relationships and subsequent phenotypic changes or adaptations in MM cells, with the aim of providing a deeper understanding of how myeloma cells grow in the skeleton to cause bone destruction. We identify avenues and therapies that intervene in these networks to stop tumor growth and/or induce bone regeneration. Overall, we aim to illustrate how novel therapeutic target molecules, proteins, and cellular mediators may offer new avenues to attack this disease while reviewing currently utilized therapies.

show abstract

Section: Myeloma Interaction With Bm Elementsmentioning

confidence: 99%

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The role of the central nervous system in bone metabolism and the specific role of adiponectin in skeletal metabolism are addressed in this issue. Moving towards the skeletal microenvironment, metabolically active marrow adipose tissue has the potential to influence and control local processes [18] and may also contribute to the development of disease such as myeloma [19]. In this issue, McDonald et al provide a comprehensive review on how cells in the bone microenvironment including adipocytes contribute to the origin of multiple myeloma, and the subsequent disease progression and drug resistance.…”

mentioning

confidence: 99%

Fat and Bone: Where are We Now?

Dimitri

Rosen

2017

Calcif Tissue Int

View full text Add to dashboard Cite

is more likely altered in response to obesity [6], although from cross sectional studies in adults that may not be the case [7]. Thus, the debate relating to the impact of obesity on the skeleton lives on. In this Special Edition of 'Fat and Bone', Farr, Dimitri and Walsh address the past and current research relating to the impact of obesity on bone in children and adults.A broad range of skeletal imaging techniques have been developed to aid our understanding of skeletal mass, size and architecture and engineering models such as finite element analysis have been applied to determine bone strength. DXA remains the gold-standard clinical means of assessing skeletal parameters [8,9], although challenges in interpreting DXA in relation to body size and proportions [10], particularly in obese children [2], and tissue thickness and distribution in [11,12] have called into question the accuracy of assessing bone mass and density in relation to increasing adiposity. At the limits of in vivo scanning resolutions, HR-pQCT provides a detailed view of trabecular and cortical microarchitecture but is limited to the distal extremities and may not reflect skeletal changes elsewhere in the skeleton. In this Special Edition, the clinical considerations and diagnostic challenges in relation to skeletal imaging of children are reviewed. The challenge ahead is the development of a scanning technique that provides an accurate assessment of skeletal microarchitecture in the appendicular and axial skeleton relevant to changes in factors affecting the skeleton such as hormonal changes and physical activity in children and adults.

show abstract

“…A handful of studies in myeloma have found that MAT produces factors that support myeloma disease progression, although certain adipokines, such as adiponectin [16], have been found to inhibit myeloma, confounding the roles of MAT in myeloma [17,18]. Cell-derived factors (molecules, lipids, small metabolites, or microRNAs) may be free or embedded in exosomes or other microvesicles and transferred between BMAs and myeloma cells as one method of communication [19].…”

Section: Mat Adipokines Lipids and Cell-cell Contact Supports Camentioning

confidence: 99%

Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes

2017

Self Cite

View full text Add to dashboard Cite

This review highlights the recent advances in our understanding of adipocyte contributions to carcinogenesis or cancer disease progression for cancers in the bone. Purpose In this review, we aim to describe bone marrow adipose tissue and discuss the soluble adipocyte-derived cytokines (adipokines) or endocrine factors, adipocyte-derived lipids, and the actual or putative juxtacrine signaling between bone marrow adipocytes and tumor cells in the bone marrow. This relationship likely affects tumor cell initiation, proliferation, metastasis, and/or drug resistance. Recent Findings Bone marrow adipose may affect tumor proliferation, drug resistance, or cancer-induced bone disease and hence may be a new target in the fight against cancer. Summary Overall, evidence is mixed regarding the role of bone marrow adipose and adipocytes in cancer progression, and more research in this arena is necessary to determine how these bone marrow microenvironmental cells contribute to malignancies in the marrow to identify novel, potentially targetable pathways.

show abstract

Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells

Cited by 73 publications

References 186 publications

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

Fat and Bone: Where are We Now?

Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes

Contact Info

Product

Resources

About