Signaling mechanisms of apoptosis-like programmed cell death in unicellular eukaryotes

Шемарова, И. В.

doi:10.1016/j.cbpb.2010.01.010

Cited by 24 publications

(18 citation statements)

References 178 publications

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“…An apoptosis option is present in all types of cells [166,167]. If DNA damage cannot be corrected or bypassed, then cell death is inevitable.…”

Section: Apoptosis Decisions In Response To Dna Damagementioning

confidence: 99%

How life changes itself: The Read–Write (RW) genome

Shapiro

2013

Physics of Life Reviews

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The genome has traditionally been treated as a Read-Only Memory (ROM) subject to change by copying errors and accidents. In this review, I propose that we need to change that perspective and understand the genome as an intricately formatted Read-Write (RW) data storage system constantly subject to cellular modifications and inscriptions. Cells operate under changing conditions and are continually modifying themselves by genome inscriptions. These inscriptions occur over three distinct time-scales (cell reproduction, multicellular development and evolutionary change) and involve a variety of different processes at each time scale (forming nucleoprotein complexes, epigenetic formatting and changes in DNA sequence structure). Research dating back to the 1930s has shown that genetic change is the result of cell-mediated processes, not simply accidents or damage to the DNA. This cell-active view of genome change applies to all scales of DNA sequence variation, from point mutations to large-scale genome rearrangements and whole genome duplications (WGDs). This conceptual change to active cell inscriptions controlling RW genome functions has profound implications for all areas of the life sciences.

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“…An apoptosis option is present in all types of cells [166,167]. If DNA damage cannot be corrected or bypassed, then cell death is inevitable.…”

Section: Apoptosis Decisions In Response To Dna Damagementioning

confidence: 99%

How life changes itself: The Read–Write (RW) genome

Shapiro

2013

Physics of Life Reviews

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“…Development of organisms depends on many physiological processes, including cell division and programmed cell death (PCD), which control proper growth of multicellular (van Doorn and Woltering 2005; Delaval and Birnbaum 2007; Hübner et al 2009) as well as unicellular organisms (Shemarova 2010). Cell division, elevating the number of cells (Delaval and Birnbaum 2007) as well as PCD, eliminating physiologically redundant, damaged or abnormal cells (van Doorn and Woltering 2005) plays an important role in the wide range of differentiation processes (Barciszewski et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings

2012

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The double fluorescence staining with acridine orange and ethidium bromide (AO/EB) revealed that treatment of Vicia faba ssp. minor seedlings with kinetin-induced programmed cell death (PCD) in root cortex cells. Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation. Decrease in the number of mitochondria and in the activity of cellular dehydrogenases, production of reactive oxygen species (ROS), appearance of small and then large lytic vacuoles and increase in the amount of cytosolic calcium ions were also observed. The PCD was also manifested by increased width and weight of apical fragments of roots as well as decreased length of cortex cells which led to shortening of the whole roots. The kinetin-induced PCD process was almost completely inhibited by adenine, an inhibitor of phosphoribosyl transferase, and mannitol, an inhibitor of ROS production. These cell-death hallmarks and pathway of this process suggested that the induction of kinetin-specific vacuolar type of death, expressed itself with similar intensity on both morphological and metabolic levels, was a transient protecting whole roots and whole seedlings against elimination.

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“…In addition, we did observe TMBP-induced typical chromatin condensation and DNA fragmentation shown by Programmed cell death (PCD) is essential for normal development and maintenance of tissue homeostasis in multicellular organisms. While it is now evident that PCD can take many different forms, apoptosis is probably the most well-defined cell death program (Shemarova, 2010). The family of cysteine proteases known as caspases plays a central role in apoptosis, contributing to a signaling cascade between death promoting stimuli and the cleavage of protein substrates which contribute to the characteristic apoptotic morpho -logy (Cohen, 1997).…”

Section: Discussionmentioning

confidence: 99%