Signaling molecules targeting cannabinoid receptors: Hemopressin and related peptides

Wei, Fengmei; Zhao, Long; Jing, Yu‐Hong

doi:10.1016/j.npep.2019.101998

Cited by 11 publications

(7 citation statements)

References 84 publications

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“…In the meantime, some efforts have been made to discover novel cannabinoids over the past few years, leading to the emergence of peptide-type ligands of CB1 and/or CB2 from natural sources, other than the cannabis plant. Examples hereof are hemopressin (Hp) and the related peptides VD-Hpα and RVD-Hpα found in mice, rats or humans, as well as Pep19 derived from peptidyl-prolyl cis-trans isomerase A in humans, showing a variety of in vivo pharmacological effects depending on CB1, e.g., antinociception and neuromodulation [ 35 , 36 ]. Moreover, Pep19 did not exhibit CNS side effects in rats [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Peigneur

Hendrickx

et al. 2020

IJMS

143

114

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Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory.

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Section: Introductionmentioning

confidence: 99%

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Peigneur

Hendrickx

et al. 2020

IJMS

143

114

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“…50 Furthermore, AEA and 2-AG have different pharmacological profiles with regard to interaction with their receptors, CB 1 and CB 2 receptors, but can also activate other receptors, such as TRPV1 and GABA A receptors, respectively. 5,21 Furthermore, endogenous peptides called pepcans or hemopressin were recently characterized [151][152][153] ; these can act on CB 1 and CB 2 receptors, thereby modifying biological processes.…”

Section: Neurobiology Of Cannabinoid Receptor Signaling -Lutzmentioning

confidence: 99%

Neurobiology of cannabinoid receptor signaling

Lutz

2020

Dialogues in Clinical Neuroscience

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The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous system. Despite its widespread localization, its functions within the context of distinct neural processes are very well discernable and specific. This is remarkable, and the question remains as to how such specificity is achieved. One key player in the ECS is the cannabinoid type 1 receptor (CB1), a G protein–coupled receptor characterized by the complexity of its cell-specific expression, cellular and subcellular localization, and its adaptable regulation of intracellular signaling cascades. CB1 receptors are involved in different synaptic and cellular plasticity processes and in the brain’s bioenergetics in a context-specific manner. CB2 receptors are also important in several processes in neurons, glial cells, and immune cells of the brain. As polymorphisms in ECS components, as well as external impacts such as stress and metabolic challenges, can both lead to dysregulated ECS activity and subsequently to possible neuropsychiatric disorders, pharmacological intervention targeting the ECS is a promising therapeutic approach. Understanding the neurobiology of cannabinoid receptor signaling in depth will aid optimal design of therapeutic interventions, minimizing unwanted side effects.

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“…From this degradation, we find hemopressin (Hp) and hemophin, which attach to cannabinoid receptors (CBr1 and CBr2) [12]. A portion of hemopressin, in particular, Hb-alpha1 can be considered a neuropeptide, capable of having anti-nociceptive effects (reduces the sensations of hyperalgesia and visceral pain), is capable of improving memory and ability to regulate the mood [13]. Hp stimulates the release of endorphins, exerting anxiolytic and antidepressant effects as allosteric agents, targeting CBr1 and CBr2 centrally [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…A portion of hemopressin, in particular, Hb-alpha1 can be considered a neuropeptide, capable of having anti-nociceptive effects (reduces the sensations of hyperalgesia and visceral pain), is capable of improving memory and ability to regulate the mood [13]. Hp stimulates the release of endorphins, exerting anxiolytic and antidepressant effects as allosteric agents, targeting CBr1 and CBr2 centrally [12,13]. Hemophin would act to promote a correct anti-inflammatory and anti-nociceptive response, always through the endocannabinoid pathway [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Hp stimulates the release of endorphins, exerting anxiolytic and antidepressant effects as allosteric agents, targeting CBr1 and CBr2 centrally [ 12 , 13 ]. Hemophin would act to promote a correct anti-inflammatory and anti-nociceptive response, always through the endocannabinoid pathway [ 12 , 13 ]. Body diaphragms must be considered as three-dimensional structures, represented on multiple planes and axes; it is a mistake to consider a body structure extrapolated from its three-dimensionality.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Five Diaphragms in Osteopathic Manipulative Medicine: Neurological Relationships, Part 1

Bordoni¹

2020

Cureus

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In osteopathic manual medicine (OMM), there are several approaches for patient assessment and treatment. One of these is the five diaphragm model (tentorium cerebelli, tongue, thoracic outlet, diaphragm, and pelvic floor), whose foundations are part of another historical model: respiratory-circulatory. The myofascial continuity, anterior and posterior, supports the notion the human body cannot be divided into segments but is a continuum of matter, fluids, and emotions. In this first part, the neurological relationships of the tentorium cerebelli and the lingual muscle complex will be highlighted, underlining the complex interactions and anastomoses, through the most current scientific data and an accurate review of the topic. In the second part, I will describe the neurological relationships of the thoracic outlet, the respiratory diaphragm and the pelvic floor, with clinical reflections. In literature, to my knowledge, it is the first time that the different neurological relationships of these anatomical segments have been discussed, highlighting the constant neurological continuity of the five diaphragms.

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Signaling molecules targeting cannabinoid receptors: Hemopressin and related peptides

Cited by 11 publications

References 84 publications

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Neurobiology of cannabinoid receptor signaling

The Five Diaphragms in Osteopathic Manipulative Medicine: Neurological Relationships, Part 1

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