Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system

Kipanyula, Maulilio J.; Kimaro, Wahabu Hamisi; Yepnjio, Faustin N.; Aldebasi, Yousef H.; Farahna, Mohammed; Kamdje, Armel Hervé Nwabo; Abdel-Magied, Eltuhami M; Etet, Paul Faustin Seke

doi:10.1016/j.cellsig.2013.12.007

Cited by 14 publications

(8 citation statements)

References 153 publications

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“…SGCs are derived from neural crest stem cells. 62 , 63 There is evidence that SGCs might retain stem cell characteristics in adult animals and are capable of dedifferentiation under certain conditions. The transcription factor Sox2 governs neural differentiation and sustains the self‐renewal of neural progenitor stem cells.…”

Section: Discussionmentioning

confidence: 99%

Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

Huang

Zdora

Buhr

et al. 2021

J Cellular Molecular Medi

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Satellite glial cells (SGCs) of the sensory ganglia are a glial cell population of the peripheral nervous system (PNS) with diverse and remarkable features. Within the past two decades, SGCs have received increasing attention in a wide field of research. In addition to studying their morphological and functional qualities, their role in pathologic states and the development of neuropathic pain has been investigated. 1 The sensory ganglia, including the trigeminal ganglion as well as the spinal ganglia (SG), also known as dorsal root ganglia (DRG), are part of the PNS and transmit sensory signals fromthe periphery towards the central nervous system (CNS).

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Section: Discussionmentioning

confidence: 99%

Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

Huang

Zdora

Buhr

et al. 2021

J Cellular Molecular Medi

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“…The transcription factor Sox10 is crucial in regulating neural crest stem cell development and differentiation (reviewed in ref. ) Sox10 is involved in Schwann cell differentiation but also preserves the neuronal potential of neural crest‐derived stem cells . Moreover, Sox 10 is expressed by migrating neural crest‐derived sympathoadrenal stem cells and its expression is required for the formation of the adrenal medulla .…”

Section: Resultsmentioning

confidence: 99%

Multipotent Glia-Like Stem Cells Mediate Stress Adaptation

et al. 2015

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The neural crest-derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of glia-like nestin-expressing progenitor cells in the adult adrenal medulla contributes to this plasticity. These glia-like cells have features of adrenomedullary sustentacular cells, are multipotent, and are able to differentiate into chromaffin cells and neurons. The adrenal is central to the body's response to stress making its proper adaptation critical to maintaining homeostasis. Our results from stress experiments in vivo show the activation and differentiation of these progenitors into new chromaffin cells. In summary, we demonstrate the involvement of a new glia-like multipotent stem cell population in adrenal tissue adaptation. Our data also suggest the contribution of stem and progenitor cells in the adaptation of neuroendocrine tissue function in general.

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“…In addition to Fgf9, other important genes, like Nrg1 in cluster 1, Timp1 in cluster 2, and Atf3 and C3 in cluster 3, were also found to be differentially expressed in SNI samples after corroborating microarray data with two other microarray datasets. Nrg1 reportedly plays a pivotal role in neural development and plasticity [41]. Wang et al demonstrated that Nrg1 upregulation reversed the signs of SNI-induced neuropathic pain in rats, and modulating Nrg1 might exhibit therapeutic value for neuropathic pain treatment [42].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Crucial Genes and Pathways Associated with Spared Nerve Injury-Induced Neuropathic Pain

et al. 2020

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Purpose. The study was aimed at elucidating the molecular mechanism underlying neuropathic pain induced by spared nerve injury (SNI). Methods. The microarray data of GSE30691 were downloaded from the Gene Expression Omnibus database, including sciatic nerve lesion samples at 3, 7, 21, and 40 days after SNI and sham control samples at 3, 7, and 21 days. Differential analysis along with Mfuzz clustering analysis was performed to screen crucial clusters and cluster genes. Subsequently, comprehensive bioinformatic analyses were performed, including functional enrichment analysis, protein-protein interaction (PPI) network and module analysis, and transcription factor- (TF-) gene and miRNA-target interaction predictions. Moreover, the screened differentially expressed genes (DEGs) were corroborated using two other microarray datasets. Results. Three clusters with different change trends over time after SNI were obtained. Protein kinase CAMP-activated catalytic subunit beta (Prkacb), complement C3 (C3), and activating transcription factor 3 (Atf3) were hub nodes in the PPI network, and fibroblast growth factor 9 (Fgf9) was found to interact with more TFs. Prkacb and Fgf9 were significantly enriched in the MAPK signaling pathway. Moreover, rno-miR-3583-5p was targeted by Fgf9, and rno-miR-1912-3p was targeted by neuregulin 1 (Nrg1). Key genes like Nrg1 and Fgf9 in cluster 1, Timp1 in cluster 2, and Atf3 and C3 in cluster 3 were screened out after corroborating microarray data with other microarray data. Conclusions. Key pathways like the MAPK signaling pathway and crucial genes like Prkacb, Nrg1, Fgf9, Timp1, C3, and Atf3 may contribute to SNI-induced neuropathic pain development in rats.

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Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system

Cited by 14 publications

References 153 publications

Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

Multipotent Glia-Like Stem Cells Mediate Stress Adaptation

Analysis of Crucial Genes and Pathways Associated with Spared Nerve Injury-Induced Neuropathic Pain

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