Signalling entrains the peripheral circadian clock

Zhang, Shan; Dai, Miao; Wang, Xu; Jiang, Shu-Heng; Hu, Li-Peng; Zhang, Xueli; Zhang, Zhigang

doi:10.1016/j.cellsig.2019.109433

Cited by 47 publications

(34 citation statements)

References 107 publications

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“…In addition to GC, feeding‐related hormones and metabolites, as well as metabolic and redox states may transmit nutritional signals to circadian clocks 52 . Endogenous fluctuations in nicotinamide adenine dinucleotide (NAD + ) cofactors and H 2 O 2 , 53,54 as well as the activity of the NAD + sensing protein deacetylase SIRT1 55‐57 can regulate circadian clocks.…”

Section: The Mammalian Circadian Systemmentioning

confidence: 99%

Mammalian circadian systems: Organization and modern life challenges

Finger

Kramer

2020

Acta Physiologica

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Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes and drives rhythmic biological functions, as well as behavioural outputs with an approximately 24‐hour period. In mammals, body clocks are hierarchically organized, encompassing a so‐called pacemaker clock in the hypothalamic suprachiasmatic nucleus (SCN), non‐SCN brain and peripheral clocks, as well as cell‐autonomous oscillators within virtually every cell type. A functional clock machinery on the molecular level, alignment among body clocks, as well as synchronization between endogenous circadian and exogenous environmental cycles has been shown to be crucial for our health and well‐being. Yet, modern life constantly poses widespread challenges to our internal clocks, for example artificial lighting, shift work and trans‐meridian travel, potentially leading to circadian disruption or misalignment and the emergence of associated diseases. For instance many of us experience a mismatch between sleep timing on work and free days (social jetlag) in our everyday lives without being aware of health consequences that may arise from such chronic circadian misalignment, Hence, this review provides an overview of the organization and molecular built‐up of the mammalian circadian system, its interactions with the outside world, as well as pathologies arising from circadian disruption and misalignment.

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Section: The Mammalian Circadian Systemmentioning

confidence: 99%

Mammalian circadian systems: Organization and modern life challenges

Finger

Kramer

2020

Acta Physiologica

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“…Tissue-specific clocks contain the molecular machinery necessary for self-sustaining rhythms [11] and have virtually the same molecular make-up as circadian oscillators in the SCN. Peripheral clocks are entrained to the external environment by the SCN via both neural and hormonal signals, as well as through non-SCN signals [12].…”

Section: Introductionmentioning

confidence: 99%

Light Pollution and Cancer

Walker

Bumgarner

Walton

et al. 2020

IJMS

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For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes and the cell cycle, as well as the contribution of clock genes to oncogenesis. Next, we review the clinical implications of disrupted circadian rhythms on cancer, followed by a section on the foundational science literature on the effects of light at night and cancer. Finally, we provide some strategies for mitigation of disrupted circadian rhythms to improve health.

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“…In addition to redox oscillations, insulin and gastrointestinal hormones can influence peripheral tissue clocks, in particular the liver clock (for review, see Ref. [99]). Insulin alters circadian rhythms by inducing protein kinase B (AKT), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K) pathways [100,101].…”

Section: Non-photic Entrainment Of Peripheral Clocksmentioning

confidence: 99%

Coupled network of the circadian clocks: a driving force of rhythmic physiology

2020

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The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment. In mammals, circadian clocks form a hierarchically organized network with a ‘master clock’ located in the suprachiasmatic nucleus of the hypothalamus, which ensures entrainment of subsidiary oscillators to environmental cycles. Robust rhythmicity of body clocks is indispensable for temporally coordinating organ functions, and the disruption or misalignment of circadian rhythms caused for instance by modern lifestyle is strongly associated with various widespread diseases. This review aims to provide a comprehensive overview of our current knowledge about the molecular architecture and system‐level organization of mammalian circadian oscillators. Furthermore, we discuss the regulatory roles of peripheral clocks for cell and organ physiology and their implication in the temporal coordination of metabolism in human health and disease. Finally, we summarize methods for assessing circadian rhythmicity in humans.

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Signalling entrains the peripheral circadian clock

Cited by 47 publications

References 107 publications

Mammalian circadian systems: Organization and modern life challenges

Mammalian circadian systems: Organization and modern life challenges

Light Pollution and Cancer

Coupled network of the circadian clocks: a driving force of rhythmic physiology

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