Congenital Anomalies - Case Studies and Mechanisms 2012
DOI: 10.5772/33099
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Signalling Mechanisms Underlying Congenital Malformation: The Gatekeepers, Glypicans

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“…We explored an alternative approach for enhancing the differentiation propensity of human induced PSCs (hiPSCs) toward VMDA neurons, based on modulating expression levels of the cell membrane protein GLYPICAN‐4 (GPC4). GPC4 is a member of the heparan sulfate proteoglycan family (HSPG) GLYPICANS, which are known to regulate developmental processes by fine‐tuning cellular responses to instructive extracellular proteins 20‐23 . Our strategy relies on the rationale that the three morphogens, SHH, WNT, and FGF, required for induction of a floor‐plate with VM identity in vivo are modulated by GPC4.…”
Section: Introductionmentioning
confidence: 99%
“…We explored an alternative approach for enhancing the differentiation propensity of human induced PSCs (hiPSCs) toward VMDA neurons, based on modulating expression levels of the cell membrane protein GLYPICAN‐4 (GPC4). GPC4 is a member of the heparan sulfate proteoglycan family (HSPG) GLYPICANS, which are known to regulate developmental processes by fine‐tuning cellular responses to instructive extracellular proteins 20‐23 . Our strategy relies on the rationale that the three morphogens, SHH, WNT, and FGF, required for induction of a floor‐plate with VM identity in vivo are modulated by GPC4.…”
Section: Introductionmentioning
confidence: 99%