Signalling pathways involved in the short-term potentiation of dopamine release by BDNF

Goggi, Julian; Pullar, Ian A.; Carney, Stephen; Bradford, H. F.

doi:10.1016/s0006-8993(03)02234-0

Cited by 67 publications

(62 citation statements)

References 32 publications

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“…Recently, it was also found that BDNF stimulates dopaminergic neurotransmission in the brain. It enhanced KCl-stimulated dopamine release in a dose-dependent manner in vitro (31)(32)(33). This potentiation was shown to be mediated via TrkB receptors and required activation of the MEK (mitogen-activated/extracellular-signal regulated kinase) and PI3K (phosphatidylinositol-3 kinase) pathways (33).…”

Section: Discussionmentioning

confidence: 97%

“…It enhanced KCl-stimulated dopamine release in a dose-dependent manner in vitro (31)(32)(33). This potentiation was shown to be mediated via TrkB receptors and required activation of the MEK (mitogen-activated/extracellular-signal regulated kinase) and PI3K (phosphatidylinositol-3 kinase) pathways (33). Furthermore, both the stimulation of dopamine release and the induction of dopamine-related behaviors by methamphetamine are significantly suppressed by pretreatment with an injection into the nucleus accumbens of either BDNF or TrkB antibody (34).…”

Section: Discussionmentioning

confidence: 99%

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Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents

et al. 2005

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Corticotrophin (ACTH) and its analogues, particularly Semax (Met-Glu-His-Phe-Pro-Gly-Pro), demonstrate nootropic activity. Close functional and anatomical links have been established between melanocortinergic and monoaminergic brain systems. The aim of present work was to investigate the effects of Semax on neurochemical parameters of dopaminergic- and serotonergic systems in rodents. The tissue content of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum was significantly increased (+25%) 2 h after Semax administration. The extracellular striatal level of 5-HIAA gradually increased up to 180% within 1-4 h after Semax (0.15 mg/kg, ip) administration. This peptide alone failed to alter the tissue and extracellular concentrations of dopamine and its metabolites. Semax injected 20 min prior D: -amphetamine dramatically enhanced the effects of the latter on the extracellular level of dopamine and on the locomotor activity of animals. Our results reveal the positive modulatory effect of Semax on the striatal serotonergic system and the ability of Semax to enhance both the striatal release of dopamine and locomotor behavior elicited by D-amphetamine.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents

et al. 2005

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“…They were able to demonstrate that the interaction between the two prominent dopamine relevant genetic polymorphisms BDNF Val66Met (rs6265) and DRD2/ANKK1 Taq IA (rs1800497) had a significant influence on gray matter volume in the ACC. The brain-derived neurotrophic factor (BDNF) modulates dopaminergic pathways (27)(28)(29), which are crucially involved in reward processing, learning, and motivation (30). BDNF has been shown to influence processes in cell growth and apoptosis and plays, therefore, a critical role in neural plasticity (31,32).…”

Section: Introductionmentioning

confidence: 99%

Interaction Effect of Functional Variants of the BDNF and DRD2/ANKK1 Gene Is Associated With Alexithymia in Healthy Human Subjects

Walter

Montag

Markett

et al. 2011

Psychosomatic Medicine

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“…The peak decay is shifted to the right, which is typically associated with alterations in dopamine transporter kinetics (Km) 3 . Finally, Figure 3C is a representative trace of the current versus time trace once the slice has been bathed in a 100 ng/mL brain-derived neurotrophic factor (BDNF) solution, which has been hypothesized to influence dopamine release dynamics 20,21 . From this representative trace, it can be seen that BDNF has the ability to enhance electrically-evoked dopamine release.…”

Section: Representative Resultsmentioning

confidence: 99%

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Maina

Khalid

Apawu

et al. 2012

JoVE

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Extensive research has focused on the neurotransmitter dopamine because of its importance in the mechanism of action of drugs of abuse (e.g. cocaine and amphetamine), the role it plays in psychiatric illnesses (e.g. schizophrenia and Attention Deficit Hyperactivity Disorder), and its involvement in degenerative disorders like Parkinson's and Huntington's disease. Under normal physiological conditions, dopamine is known to regulate locomotor activity, cognition, learning, emotional affect, and neuroendocrine hormone secretion. One of the largest densities of dopamine neurons is within the striatum, which can be divided in two distinct neuroanatomical regions known as the nucleus accumbens and the caudate-putamen. The objective is to illustrate a general protocol for slice fast-scan cyclic voltammetry (FSCV) within the mouse striatum. FSCV is a well-defined electrochemical technique providing the opportunity to measure dopamine release and uptake in real time in discrete brain regions. Carbon fiber microelectrodes (diameter of~7 μm) are used in FSCV to detect dopamine oxidation. The analytical advantage of using FSCV to detect dopamine is its enhanced temporal resolution of 100 milliseconds and spatial resolution of less than ten microns, providing complementary information to in vivo microdialysis. Video LinkThe • There are numerous carbon fiber microelectrodes fabrication methods since most are made in-house. Typically what dictates the electrode fabrication details is the electrochemical technique that is applied to the electrode (e.g. amperometry vs. FSCV). For FSCV, microelectrodes can be made in-house using the following three-step procedure. For a more complete description of carbon fiber electrode fabrication, see a recent JOVE article 1 . However, note that the electrodes described below are cylindrical carbon fiber microelectrodes, which require fewer steps to fabricate versus the amperometric carbon fiber microelectrodes from the above-mentioned protocol. This simplified protocol does not require boiling the carbon fiber in acetone, fire-polishing the glass capillaries, or using epoxy to seal the glass-fiber junction.• Using vacuum suction aspirate a carbon fiber (diameter 7 μm; Goodfellow Oakdale, PA) into a borosilicate glass capillary with microfilament (length 10 cm, o.d. 1.2 mm, i.d. 0.68 mm; A-M systems, Carlsborg, WA).• Place the threaded capillary into the electrode puller (Narishige, Tokyo, Japan) where the capillary is pulled in half. Output settings for the electrode puller do vary from lab to lab. For reference, our output settings for the puller are 90.7 main magnet, 23.2 sub-magnet, and 53.4 for the heater. The output settings should be empirically refined to generate a glass taper that is approximately 4.4 mm in length, with a tight seal around the carbon fiber.• Under a microscope (Olympus, Tokyo, Japan), trim the carbon fiber (using a scalpel blade) extending from the glass tip allowing approximately 50-200 μm of the carbon fiber to protrude from the tightly sealed interface.• S...

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Signalling pathways involved in the short-term potentiation of dopamine release by BDNF

Cited by 67 publications

References 32 publications

Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents

Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents

Interaction Effect of Functional Variants of the BDNF and DRD2/ANKK1 Gene Is Associated With Alexithymia in Healthy Human Subjects

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

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