Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Stevens, Kim; O'Neill, D G; Jepson, Rosanne; Holm, Laura; Walker, David; Cardwell, Jacqueline M.

doi:10.1136/vr.104891

Cited by 14 publications

(25 citation statements)

References 9 publications

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“…After accounting for other variables, 23 breeds with more than 4 cases showed elevated odds of osteosarcoma compared to crossbreeds and, of these breeds, the Rottweiler, Rhodesian Ridgeback and Great Dane had over ten times the odds. Although the Rottweiler and Great Dane have been reported as at-risk breeds previously, the current study is the rst to identify predisposition for the Rhodesian Ridgeback [2,4,5,9,11,12,24]. Rhodesian Ridgebacks could have been omitted from previous work owing to selection bias, which refers to a scenario in which the composition of the study group differs from the source population, and this biases the association between exposure and outcome [33,34].…”

Section: Breed Variablementioning

confidence: 99%

“…Furthermore, it was hypothesised that purebred dogs in general have higher odds of osteosarcoma than crossbreeds. Since reportedly predisposed breeds possess large body mass, a related hypothesis was that heavier weight categories have higher odds of osteosarcoma [2,5,9,12,24]. Secondary to the breed and body mass hypotheses, we also proposed that dogs with conditions which become inherited during breeding for short leg length, such as chondrodystrophy, would be protected from osteosarcoma compared with non-chondrodystrophic breeds [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Dog Breeds and Body Conformations with Predisposition to Osteosarcoma in the UK: A Case-Control Study

Edmunds

Smalley

Beck

et al. 2020

Preprint

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BackgroundOsteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds including the Rottweiler are associated with elevated osteosarcoma risk. However, these studies were often limited by selection bias and confounding, and have rarely offered insights into breed-associated protection as well as breed-associated predisposition for osteosarcoma. The current study includes 1756 osteosarcoma cases presenting to VPG Histology (Bristol, UK) that are compared against a control population of 905,211 dogs without osteosarcoma taken from primary care electronic patient records in the VetCompass™ dataset. Methods and Study DesignRetrospective, case-control study. Multivariable logistic regression analysis explored associations between demographic risk factors (including breed, chondrodystrophy, age, sex/neuter status, skull-shape, and body mass) and osteosarcoma. ResultsWe identified several breeds with increased and reduced odds of osteosarcoma. At highest risk were the Rottweiler and Great Dane, with >10 times the odds of osteosarcoma compared with crossbreeds, and the Rhodesian Ridgeback; which has not featured in previous lists of at-risk breeds for osteosarcoma, and had an odds ratio of 11.31 (95% confidence interval 7.37 - 17.35). Breeds at lowest risk of osteosarcoma (protected breeds) included the Bichon Frise, the French Bulldog and the Cavalier King Charles Spaniel, all with odd ratios of less than 0.30 compared with crossbreeds. Body mass was strongly associated with osteosarcoma risk; dogs over 40kg exhibited osteosarcoma odds of 45.44 (95% confidence interval 33.74 - 61.20) compared with dogs less than 10kg. Chondrodystrophic breeds had an osteosarcoma odds ratio of 0.13 (95% confidence interval 0.11 - 0.16) compared with non-chondrodystrophic breeds. ConclusionsOverall, this study provides evidence of strong breed-associated osteosarcoma risk and protection, suggesting a genetic basis for osteosarcoma pathogenesis. The study findings highlight that breeds bred for long legs or large body mass are generally overrepresented amongst at-risk breeds, whilst those bred for short leg length or small body mass are generally protected. These findings could inform genetic studies to identify osteosarcoma risk alleles in canines and humans; as well as increasing awareness amongst vets and owners, resulting in improved breeding practices and clinical management of osteosarcoma in dogs.

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Section: Breed Variablementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dog Breeds and Body Conformations with Predisposition to Osteosarcoma in the UK: A Case-Control Study

Edmunds

Smalley

Beck

et al. 2020

Preprint

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“…Also priortised at the 3rd IDHW was movement towards open access publication to encourage wider disemination of research findings and there is some evidence that research papers are increasingly likely to be published as open access since then [37,53,54]. There has also been evidence of increased research output on two key areas identified as priorities at the 3rd IDHW 2017: disease prevalence/incidence, risk factors, and geographic spread [53,[55][56][57][58] and also quality-of-life and end-of-life data [59,60].…”

Section: Ipfd Harmonization Of Genetic Testing For Dogs: An Internatimentioning

confidence: 99%

Moving from information and collaboration to action: report from the 4th international dog health workshop, Windsor in May 2019

Pegram

Bonnett

Skarp

et al. 2020

Canine Genet Epidemiol

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Background: Dogs are the most popular mammal kept as a companion animal globally. Positive human-dog relationships can benefit both the human owners as well as the dogs. However, popularity as a companion animal species does not universally benefit dogs in reverse. Breed-related health problems in dogs have received increasing attention over the last decade, sparking increased concerns for dog welfare across many stakeholders. Progress towards improved welfare requires meaningful collaboration between all those working in dog health, science and welfare. The International Partnership for Dogs (IPFD), together with an alternating host organisation, holds biennial meetings called the International Dog Health Workshops (IDHW). The IPFD 4th IDHW was hosted by the UK Kennel Club in Windsor, UK in May 2019. With the aim of encouraging international and multi-stakeholder collaborations that are effective and ongoing, the 4th IDHW 2019 provided a forum to identify specific needs and actions that could improve health, well-being and welfare in dogs, building on outcomes and evaluating actions of previous IDHWs. Results: The workshop included 126 decision-leaders from 16 countries and was structured around five key themes identified as needing international, multi-stakeholder attention. These included the concept of "breed", supply and demand, breed-specific strategies for health and breeding, genetic testing and extreme conformations. The review of progress made since the 3rd IDHW 2017 and the comprehensive lists of actions agreed upon during the current meeting suggest that movement from information and collaboration to action has been achieved. Working groups with specific tasks were identified and many plan to continue to communicate through forum communities on DogWellNet.com.

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“…The aetiology is unknown although multiple possibilities have been proposed, including ingestion of bacteria-associated shiga toxin [1, 2, 4, 5, 7, 8, 10] However, studies have failed to consistently identify the presence of shiga toxin, or bacteria or viruses within tissues from affected cases [1, 4, 5]. Electron microscopy with immunostaining has also failed to identify immune-complex deposition in affected cases [4, 5, 8].…”

Section: Introductionmentioning

confidence: 99%

“…Electron microscopy with immunostaining has also failed to identify immune-complex deposition in affected cases [4, 5, 8]. Despite this, several risk factors for development of the condition have been identified, including being from the hound or gundog Kennel Club groups, and certain individual breeds such as English springer spaniel, flat-coated retriever, Hungarian vizsla and whippet, and being female and neutered [10]. The majority of diagnoses are made between November and May, and case distribution is strongly linked to woodland habitats [11].…”

Section: Introductionmentioning

confidence: 99%

Canine cutaneous and renal glomerular vasculopathy in the Republic of Ireland: a description of three cases

et al. 2019

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BackgroundCutaneous and renal glomerular vasculopathy (CRGV) is a condition of unknown aetiology involving microvascular thrombosis. It has recently been described in over 160 dogs in the United Kingdom and usually has a grave prognosis. To date, this condition has not been described in dogs residing in the Republic of Ireland.Case presentationThree dogs presented to University College Dublin Veterinary Hospital (UCDVH) for investigation of rapidly progressive skin lesions. All dogs were diagnosed with CRGV on post-mortem examination. All three dogs had azotaemia on presentation or rapidly developed azotaemia, and all were euthanased because of progression of clinical signs and likelihood of CRGV. One dog was affected by seizure-like episodes and had thrombotic microangiopathy evident within the cerebrum.ConclusionsCRGV occurs in dogs residing in the Republic of Ireland and is a differential for cases presenting with skin lesions and azotaemia. The histopathological lesions of CRGV can also affect the brain leading to neurological signs such as seizures. Owners and veterinarians should be aware that this condition can occur in dogs in Ireland.

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Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Cited by 14 publications

References 9 publications

Dog Breeds and Body Conformations with Predisposition to Osteosarcoma in the UK: A Case-Control Study

Dog Breeds and Body Conformations with Predisposition to Osteosarcoma in the UK: A Case-Control Study

Moving from information and collaboration to action: report from the 4th international dog health workshop, Windsor in May 2019

Canine cutaneous and renal glomerular vasculopathy in the Republic of Ireland: a description of three cases

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