Signature reversion of three disease‐associated gene signatures prioritizes cancer drug repurposing candidates
Jennifer L. Fisher,
Elizabeth J. Wilk,
Vishal H. Oza
et al.
Abstract:Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identify drugs that may reverse that signature. We assessed the performance and biological relevance of three approaches for constructing disease‐associated gene signatures (i.e., limma, DESeq2, and MultiPLIER) and prioritized the resulting drug repurposing candidates for … Show more
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