Signatures of metabolic diseases on spermatogenesis and testicular metabolism

Carrageta, David F.; Pereira, Sara C.; Ferreira, Rita; Monteiro, Mariana P.; Oliveira, Pedro F.; Alves, Marco G.

doi:10.1038/s41585-024-00866-y

Cited by 9 publications

(2 citation statements)

References 207 publications

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“…Testicular metabolic memory can result in persistently lower sperm quality despite improved metabolic health [ 120 ]. This involves lasting epigenetic changes and oxidative stress in the testes, impairing spermatogenesis [ 121 ].…”

Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%

“…It has been shown that a WD can reprogram the innate immune system and induce low-grade inflammation [ 141 ]. The WD lead to increased postprandial insulin production and may result in insulin oversecretion and hyperinsulinemia, promoting fat accumulation, inhibiting lipolysis, and causing increased appetite, hyperphagia, and weight gain [ 121 , 139 ]. An increasing body of evidence suggests that GM is adversely affected by the WD, promoting inflammation due to both structural and behavioral changes in the resident bacteria, and these alterations are associated with obesity and subsequent hormonal changes [ 142 ].…”

Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%

See 1 more Smart Citation

Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts

Mazza,

Troiano,

Ferro

et al. 2024

Nutrients

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Understanding the intricate relationship between nutrition, hormonal balance, and gender-specific factors is crucial for developing targeted interventions to mitigate obesity-related endocrine disruptions and improve metabolic health. This narrative review examines the impact of various dietary patterns on hormonal regulation in both men and women, focusing on their effects on hormonal balance and metabolic health in the context of obesity. Calorie restriction, the Western diet, high-fat diets, low-CHO diets, plant-based diets, and the Mediterranean diet are analyzed in relation to their influence on obesity-related endocrine disruptions and metabolic health. Future research directions include investigating the specific mechanisms underlying dietary influences on hormonal regulation, addressing the gender-specific metabolic differences and body fat distribution, and exploring the dietary needs of individuals undergoing gender transition. Personalized dietary interventions tailored to individual metabolic and hormonal profiles are essential for optimizing health outcomes across the gender spectrum. By integrating gender-specific considerations into dietary recommendations, healthcare professionals can better support individuals in achieving optimal metabolic health and hormonal balance.

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Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%