We study a three-dimensional time-reversal-invariant topological superconductivity in materials with the noncentrosymmetric B20 cubic structure such as RhSi, CoSi, and AlPt which host coupled multifold nodes energetically split by the spin-orbit coupling at the same time-reversal-invariant momentum (TRIM). The topological superconductivity arises from the s+ ⊕ s− gap function, which is k-independent, but with opposite signs for the two nodes split at the same TRIM. We consider various electron-electron interactions in the tight-binding model for RhSi and find that the topological superconducting phase supporting a surface Majorana cone and topological nodal rings (NRs) is favored in a wide range of interaction parameters.