Signet ring cell carcinoma mimicking ileal Crohn’s disease

Doğan, Serkan; Celıkbılek, Mehmet; Yagbasan, Ahmet; Sezgin, Gülten Can; Gürsoy, Şebnem; Denız, Kemal

doi:10.4081/gi.2013.e2

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that is identified most frequently in the stomach, where it accounts for 25% of all gastric cancers. SRCC has also been detected in the pancreas, breasts, bladder, ovaries, esophagus, lungs, and large intestine [ 2 , 3 ]. The five-year survival rate of patients diagnosed with SRCC has been estimated at 20–30% [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge—Case Report and Review of the Literature

Martins

Umar

Groudan

et al. 2022

Case Reports in Gastrointestinal Medicine

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Malignancies of the small intestine are rare. Signet-ring cell carcinoma (SRCC) is one of the rarest forms of adenocarcinoma that can arise in the small intestines. We present a case of a patient who originally presented with abdominal pain and radiographic findings suggestive of ileal congestion. The ileal biopsy specimens were nonspecific, and the patient began a trial of corticosteroid treatment for suspected Crohn’s disease. A repeat colonoscopy yielded biopsies that were positive for malignancy. The patient then underwent an exploratory laparotomy which led to the diagnosis of SRCC. Given their similar presentations and the extreme rarity of this unusual malignancy, it can be difficult to differentiate between new-onset Crohn’s disease and SRCC. A review of the literature was conducted to provide us with an improved understanding of previously documented cases of SRCC.

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Section: Introductionmentioning

confidence: 99%

Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge—Case Report and Review of the Literature

Martins

Umar

Groudan

et al. 2022

Case Reports in Gastrointestinal Medicine

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“…It is an epithelial malignancy with cells resembling signet rings, as they contain large amounts of mucin, which pushes the nucleus to the cell periphery [1] . It represents one fourth of gastric cancers but in other locations has a very low incidence (<1%) [2] . The survival rate is poor (20-30% at 5 years) [1] .…”

Section: Introductionmentioning

confidence: 99%

“…Signet ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that most often arises in the stomach but may affect other organs, including the pancreas, breast, urinary bladder, ovarian, lung, esophagus, and large intestine [2,3] . It is an epithelial malignancy with cells resembling signet rings, as they contain large amounts of mucin, which pushes the nucleus to the cell periphery [1] .…”

Section: Introductionmentioning

confidence: 99%

Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both - A Case of Diagnostic Challenge

Carvalho¹,

Tavares²,

Goulart³

et al. 2017

GE Port J Gastroenterol

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ResumoO carcinoma de células em anel de sinete é uma forma rara de adenocarcinoma que afeta predominantemente o estômago. A forma primária do íleon é muito rara e apresenta mau prognóstico. Apresentamos um caso de doença de Crohn do íleon cuja forma de apresentação cursou com quadro oclusivo associado a adenocarcinoma de cé-lulas em anel de sinete do íleon. A doente apresentava história prévia de diarreia crónica e tinha história familiar de doença inflamatória. Foi submetida a ressecção cirúr-gica e os achados histopatológicos revelaram a presença de aspetos compatíveis com doença de Crohn do íleon e adenocarcinoma de células em anel de sinete. Foi proposta uma associação com esta forma rara de tumor e infla- Keywords Signet ring cell carcinoma · Crohn disease · Ileum AbstractSignet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. Signet ring cell carcinoma originated from the ileum is extremely rare and the prognosis is poor. We present a case of small bowel obstruction with features suggesting Crohn disease of the ileum. The symptoms were chronic diarrhea and abdominal pain with a family history of inflammatory bowel disease. The patient underwent surgery and histopathology revealed both aspects of signet ring cell carcinoma and Crohn disease of the ileum. An association between long-standing inflammation and the development of this subtype of tumor has been proposed but there are no established surveillance guidelines for small bowel neoplasm in inflammatory bowel disease. 48 mação de longa duração, contudo, não existem recomendações estabelecidas de vigilância de neoplasia na doença inflamatória intestinal com atingimento ileal.

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Signet ring cell carcinoma mimicking ileal Crohn’s disease

Cited by 2 publications

References 11 publications

Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge—Case Report and Review of the Literature

Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge—Case Report and Review of the Literature

Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both - A Case of Diagnostic Challenge

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