Signet Ring Cell Carcinoma of the Duodenal Bulb With Metastases to the Ovaries and the Colon: A Case Report

Henry,

doi:10.4021/jmc1223w

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…8 Henry et al reported a case of signet ring cell carcinoma of duodenal bulb with metastasis to ovaries and colon. 9 None of these reports showed a radical resection with curative intent and long-term follow up and survival. Therefore, this is a rare case scenario in which highly aggressive duodenal carcinoma with isolated ovarian metastasis in good performance status patient, radical surgery is still feasible and can be offered if possible.…”

Section: Discussionmentioning

confidence: 99%

Radical resection for duodenal carcinoma with isolated bilateral ovarian metastasis: a case report

et al. 2019

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Natural history of duodenal adenocarcinoma is not well known. Although extremely rare, the incidence of primary small bowel adenocarcinoma has been increasing. Primary duodenal cancer is a very rare, which has accounted for only 0.3% of all gastrointestinal cancers. Isolated ovarian metastasis from duodenal carcinoma is extremely rare entity. We report a case of duodenal carcinoma with isolated bilateral ovarian metastasis in a 39-year-old female patient managed surgically with Whipple’s procedure with bilateral oophorectomy. She presented with complaints of dyspepsia and intermittent vomiting since 1½ years. History of anorexia and weight loss present. Upper gastrointestinal endoscopy was suggestive of circumferential ulcerated friable lesion at duodenum (D1-2) region and histopathology suggestive of moderately differentiated adenocarcinoma. Subsequent imaging studies revealed 6×5 cm duodenal mass in D1 and D2 without IHBRD with right ovarian mass. She underwent staging laparoscopy with open classic Whipple’s procedure with bilateral oophorectomy was done. Intraoperatively 6×6 cm mass involving first and second part of duodenum involving head of pancreas was found with 3×3 cm right ovarian mass. Post-operative period was uneventful and she discharged on POD6. Final biopsy was suggestive of moderately differentiated adenocarcinoma of duodenum with bilateral ovarian metastasis and she received adjuvant chemotherapy. Now at 1 year, on regular follow up she is completely asymptomatic and imaging showed no recurrent disease. Isolated ovarian metastasis may not be a contraindication for radical surgery in selected group of patients with duodenal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Radical resection for duodenal carcinoma with isolated bilateral ovarian metastasis: a case report

et al. 2019

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“…We also found 1 report where SRCC of the duodenum spread to the ovaries, peritoneum, and colon, and on endoscopy, there was an exophytic obstructing duodenal bulb mass. 14 SRCC is a unique histologic subtype of CRC and is defined as a poorly cohesive carcinoma 15 where greater than 50% of tumor cells show abundant cytoplasm mucin and eccentric crescentshaped nuclei. 16 SRCC in the distal gastrointestinal tract comprises 1% of all cases of colon cancer and 15.3% of all SRCC cases.…”

Section: Discussionmentioning

confidence: 99%

“…We also found 1 report where SRCC of the duodenum spread to the ovaries, peritoneum, and colon, and on endoscopy, there was an exophytic obstructing duodenal bulb mass. 14 …”

Section: Discussionmentioning

confidence: 99%

The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum

Tom,

Placone,

Yung

et al. 2023

ACG Case Rep J

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Colorectal cancer (CRC) metastasizing to the stomach and duodenum is rare. Even rarer is when the CRC subtype is signet-ring cell carcinoma (SRCC). Endoscopic findings of CRC metastasis to the stomach have been described as solitary and submucosal while duodenal metastasis has been observed to be exophytic. In this report, we describe a case of a middle-aged man with colon SRCC presenting with oral intolerance. He was found to have concurrent metastases to the stomach and duodenum and died 8 months after his SRCC diagnosis.

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Signet Ring Cell Carcinoma of the Duodenal Bulb With Metastases to the Ovaries and the Colon: A Case Report

Abstract: Primary duodenal cancer is a rare entity which has accounted for only 0.3% of all gastrointestinal cancers.

Cited by 2 publications

References 9 publications

Radical resection for duodenal carcinoma with isolated bilateral ovarian metastasis: a case report

Radical resection for duodenal carcinoma with isolated bilateral ovarian metastasis: a case report

The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum

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