Signet Ring Cell Carcinoma of Ampulla of Vater: Report of a Rare Malignancy and Literature Review

Souaf, Ihsane; Znati, Kaoutar; Chahbouni, Sanae; Hafid, I.; Ameurtesse, Hassania; Hammas, N; Chbani, Leila; Fatemi, Hinde El; Harmouch, Tawfik; Amarti, Afaf

doi:10.4236/crcm.2014.33035

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Biopsy taken revealed SRCC of the ampulla of Vater like our case, although the resected specimen in their case revealed lymphatic and vascular invasion too. Souaf et al (2014) reported an instance of the same condition with duodenal invasion [ 16 ]. The lymph nodes were not involved and there was no evidence of any distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Dawande¹,

Akhtar²,

Wankhade³

et al. 2022

Cureus

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Signet ring cell carcinoma (SRCC) is a rare lesion in the gastrointestinal tract. Further, the condition is very uncommon at the ampulla of Vater. A majority of the reported cases are typical, gland-forming adenocarcinomas. In our case, a patient aged 59 years, was diagnosed as a case of peri-ampullary carcinoma based on physical exam findings and imaging. Ultrasonography (USG) abdomen and magnetic resonance cholangiopancreatography (MRCP) revealed an enlarged common bile duct (CBD) and there was a presence of stricture at the terminal CBD. Endoscopic retrograde cholangiopancreatography (ERCP) showed growth at the ampulla of Vater. An endoscopic ultrasound guided needle core biopsy was obtained. Histopathological examination revealed the case as SRCC at the ampulla of Vater. We present this as an uncommon case of SRCC at the ampulla of Vater.

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Section: Discussionmentioning

confidence: 99%

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Dawande¹,

Akhtar²,

Wankhade³

et al. 2022

Cureus

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Missed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecystectomy

Goto,

Fujii-Lau,

Wong

2024

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Background: Early cholecystectomy has been recommended for patients with acute cholecystitis and gallstone pancreatitis. However, patients with pancreaticobiliary malignancy may present acutely with similar symptoms. We hypothesize that the diagnoses of these malignancies may potentially be delayed as an unintended consequence of expedited cholecystectomies. This study reviews a cohort of patients who underwent pancreaticoduodenectomy (PD) to identify those who underwent a separate cholecystectomy before their PD. Methods: We retrospectively reviewed 162 PDs performed between 2012 and 2022. Data collected included: demographics, disease etiology and the presence of cholelithiasis. We identified patients who had a previous cholecystectomy and the time elapsed before PD as well as procedures done during the interval. We reported detailed case summaries on those patients who had a cholecystectomy within 1 year of PD. Results: In the entire cohort, mean age was 65 years, 54% were males, and 83% had a malignant reason for PD. Thirty-one patients had cholelithiasis with 23 (14%) patients having had previous cholecystectomy. Six patients had cholecystectomy within 1 year of PD. They had the following malignancies: ampullary-3, pancreas-1, cholangiocarcinoma-1 and neuroendocrine-1. Four of these patients had expedited cholecystectomy on their index hospital admission and were later found to have a periampullary malignancy with further work up. Conclusions: Pancreaticobiliary malignancies can be difficult to diagnose, and surgeons should not overlook these potential diagnoses when considering expedited cholecystectomy. Future studies in large cohorts are needed to identify high risk candidates who should undergo more detailed testing to exclude malignancy before proceeding with cholecystectomy.

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Signet Ring Cell Carcinoma of Ampulla of Vater: Report of a Rare Malignancy and Literature Review

Cited by 2 publications

References 9 publications

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Missed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecystectomy

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