Signet-Ring-Cell Carcinoma of Stomach Metastatic to the Bladder

Abstract

Bladder involvement by a secondary tumor is very rare, and a SRC carcinoma metastatic to the bladder, albeit extremely rare, should be considered in the differential diagnosis.

Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer

“…Interestingly, neogenin-1 was highly detected in signet ring cell carcinoma of diffuse type gastric cancer tissues (Fig. 1D-E), which has a metastatic property on the various cancer types [32-34]. …”

“…In human tissues of gastric cancer patients, the expression level was highly detected in malignant tissues than normal counterparts, especially in diffuse type of signet ring cell carcinomas. It may provide the cue that neogenin-1 is involved in motility of gastric cancer cells, because signet ring cell carcinoma has a metastatic property on the various cancer types [32-34]. Neogenin-1 ligands netrin-1 and RGMa were expressed at low levels or not at all in gastric cancer cells, respectively.…”

An unusual case of gastric signet-ring cell adenocarcinoma metastasizing to the urinary bladder

“…Primary adenocarcinoma of the bladder is also rare (<2%), with primary signet-ring cell carcinoma first being described in 1955 by Saphir, accounting for only 0.2% of all primary bladder cancers. 2 Bladder involvement by a secondary tumor is also comparatively rare (1-2%), with a higher incidence of secondary involvement by direct extension from the surrounding visceral organs (e.g., the colon, prostate, or cervix) compared to metastasizing from lymphatic, hematogenous, or peritoneal spread, which occur most commonly from the stomach (4.3% of all secondary bladder neoplasms), skin (3.9%), lung (2.8%), and breast (2.5%). 3 A challenge then arises because many of these secondary tumors are also commonly adenocarcinoma in histology, thus posing a diagnostic dilemma, requiring them to be differentiated from primary adenocarcinoma of the bladder.…”

Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature

“…Histologically, bladder adenocarcinomas represent less than 2% of primary bladder tumors and 54% of secondary tumors [ 17 ]. Primary SRC bladder adenocarcinomas are much more rare and account for 0.24% of all bladder malignancies [ 18 , 19 ]. SRC histology is more common in gastrointestinal system tumors and particularly in gastric cancer and is seen in 3.4% to 39% of the patients [ 20 ].…”