Signet Ring Cell Lymphoma with Plasmacytic Differentiation in a Pig

Abstract

ABSTRACT. A case of signet ring cell lymphoma in a 3-year-old mixed-breed sow is described. Macroscopical examination revealed enlargement of superficial, thoracic and abdominal lymph nodes and multiple tumor masses in the liver. The neoplastic tissue was composed of follicle center-like structures, in which neoplastic cells with Russell bodies were conspicuous. The bodies were immunostained for IgM (κ), and corresponded to moderately dense amorphous material within markedly distended cisternae of rough endoplasmic reticulum (RER) at the ultrastructural level. In contrast to typical signet ring cell lymphoma, the component cells of which resemble follicular center B lymphocytes with poorly developed RER, most neoplastic cells had features of plasma cells characterized by a cartwheel arrangement of heterochromatin and development of RER. Signet ring cells frequently had one or a few large Russell bodies occupying the entire cytoplasm, which may have been caused by abundant synthesis and defective secretion of immunoglobulin.

Mantle Cell Lymphoma with Histological Progression to Pleomorphic Lymphoma in Two Cattle

“…A case of B-immunoblastic lymphoma evolving from a mantle cell lymphoma has been reported in humans, but the transition of mantle cell lymphoma to centroblastic lymphoma (diffuse cell) has not (Feller & Diebold 2004). The presence of cIg may be observed in follicular or follicle center cell lymphomas and more mature cells in cattle and swine (Kadota & Niibori 1985, Kadota et al 1986, Kadota & Nakajima 1988, Kameyama et al 2003, Honda et al 2009, Murayama et al 2011, Nishijo et al 2013, Hagiwara et al 2014. The absence of cIg in human and bovine mantle cell lymphomas can be explained by the fact that mantle cells correspond to naive pre-germinal center B cells (Feller & Diebold 2004).…”

B‐cell lymphoma with Mott cell differentiation in a cat

“…Signet ring cell lymphoma (SRCL) is a rare variant of human non‐Hodgkin lymphoma, proposed originally by an earlier report and characterized by the proliferation of malignant lymphoid cells with cytoplasmic inclusions that displace the nucleus to the periphery of the cell . Signet ring cell lymphoma of the B‐cell type is a cytologic variant of follicular lymphoma in people and pigs . In domestic animals, B‐cell lymphomas with similar morphologic features as SRCL were reported as B‐cell lymphoma with Mott cell differentiation .…”

Neoplasmas em suínos: 37 casos

“…Isso ocorre por se tratar de uma espécie quase que unicamente de exploração econômica em que a grande maioria da população é abatida antes de atingir a "idade de câncer" (Sobestiansky et al 1999, Stalder et al 2012. Nos suínos a maioria dos neoplasmas observados são os que afetam animais jovens, incluindo linfoma (Rocha et al 2011, Ogihara et al 2012, Nishijo et al 2013, nefroblastoma e melanoma (Okomo-Adhiambo et al 2012). Estes tumores geralmente não causam sinais clí-nicos e na maioria das vezes são diagnosticados no abate, como lesões incidentais (Morés & Driemeier 2012).…”