Signet ring cell mesothelioma; A diagnostic challenge

Wang, Hui; Herath, Chaturika

doi:10.1016/j.prp.2019.152462

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Immuno‐markers can prove useful in differentiating these cells from those of adenocarcinoma. But sometimes metastasis of signet‐ring cells of primary breast carcinoma show immunocytochemical overlap including positivity for GATA3 and ER as well as negativity for BER‐EP4 causing considerable dilemma 20 . An extensive clinical‐pathological correlation at this stage helps in forming the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“Single‐cell pattern” of adenocarcinoma cells in effusion cytology: Morphologic challenges of lung cancer

Guleria

Barwad

Malik

et al. 2020

Diagnostic Cytopathology

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Background Lung adenocarcinomas present as tight clusters and three‐dimensional balls in effusion specimens. Unlike carcinomas of breast and stomach where singly lying malignant cells are seen in effusion samples, lung adenocarcinomas usually show cohesive morphology. This single‐cell pattern may also be confused with reactive mesothelial cells. We studied the frequency of pulmonary adenocarcinoma with single‐cell pattern cytomorphology in pleural effusion specimens. Materials and Methods All cases reported as either suspicious or positive for malignancy on pleural effusion cytology (PFC) over the past 1 year were retrieved. The clinical details were obtained from requisition forms. Cases with predominant single‐cell pattern, clinically suspicious of carcinoma lung were segregated. These were de‐stained and immunocytochemistry (ICC) for TTF‐1 was performed. Results Of 103 cases reported as either suspicious or positive for malignancy on PFC, 29 had a predominant single‐cell pattern. Of these, 13 (44.8%) were primary lung carcinoma. The rest were metastasis from ovary (5; 17.2%), breast (2; 6.9%), stomach (2; 6.9%), lymphoma (1; 3.5%), and Ewing's sarcoma (1; 3.5%). Five (17.2%) were those with unknown primary. All cases of lung carcinoma were positive for TTF‐1 ICC. Conclusion Single‐cell pattern of pulmonary adenocarcinoma is commoner than popularly believed. This pattern may be difficult to differentiate from carcinoma cells of other sites as well as from reactive mesothelial cells. A high degree of suspicion is therefore needed to perform relevant ICC to clinch the correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

“Single‐cell pattern” of adenocarcinoma cells in effusion cytology: Morphologic challenges of lung cancer

Guleria

Barwad

Malik

et al. 2020

Diagnostic Cytopathology

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“…The prognosis is poor, with reported mean survival of 8.2 months (41). Signet ring cell variant seems to be even rarer than previous two variants, with so far less than 30 reported cases, majority involving the pleura (42). Median survival was 15 months (43), and the major diagnostic challenge is ruling out the metastasis.…”

Section: Epithelioid Malignant Mesothelioma (Emm)mentioning

confidence: 99%

Clinical significance of histologic subtyping of malignant pleural mesothelioma

Brčić¹,

Kern²

2020

Transl Lung Cancer Res

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Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.

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“…Overlapping of mesothelioma cell clusters is relatively rare as compared to that seen with an adenocarcinoma, as they are generally flat [11]. Mesothelioma cells showing a signet cell-like ring are also occasionally noted [12].…”

Section: General Cytological Features Of Epithelioid Type Of Mpmmentioning

confidence: 99%

Malignant mesothelioma: Cytological features

Okimura¹

2022

Open J Clin Med Images

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A malignant mesothelioma arises from the serosal surface of the pleural, peritoneal, or pericardial cavity. Although rare, with development of diagnostic techniques, the frequency of this tumor has been increasing. Malignant mesothelioma is classified into three types; epithelioid, sarcomatoid, and biphasic. It is especially important to differentiate epithelioid type from reactive mesothelial cells and another type of carcinoma, with a definitive diagnosis usually obtained based on examination of tissue biopsy or surgical resection specimens.

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Signet ring cell mesothelioma; A diagnostic challenge

Cited by 9 publications

References 23 publications

“Single‐cell pattern” of adenocarcinoma cells in effusion cytology: Morphologic challenges of lung cancer

“Single‐cell pattern” of adenocarcinoma cells in effusion cytology: Morphologic challenges of lung cancer

Clinical significance of histologic subtyping of malignant pleural mesothelioma

Malignant mesothelioma: Cytological features

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