Signet‐ring lymphoma: Report of a case

Abstract

Signet-ring lymphoma is a rare entity in which the synthesis or secretion of immunoglobulins is impaired, producing a signet-ring appearance to the lymphoma cells. A case of this type of lymphoma is described, and the cytologic aspects of the cells obtained from the fixative fluid are described.

Fine‐needle aspiration diagnosis of lymphomas with signet ring cell features

“…[8][9][10][11] However, to the best of our knowledge, the cytologic features of LSF have been only sparsely reported. To date, 7 single case reports have appeared in the cytology literature, [12][13][14][15][16][17][18] with only 5 of these cases being diagnosed in fine-needle aspiration (FNA) samples. [12][13][14]16,18 FNA is a simple, fast, minimally invasive, costeffective procedure that is often used as an initial diagnostic tool to evaluate primary or metastatic/recurrent tumors at virtually any site in the human body.…”

“…However, to the best of our knowledge, the cytologic features of LSF have been only sparsely reported. To date, 7 single case reports have appeared in the cytology literature, with only 5 of these cases being diagnosed in fine‐needle aspiration (FNA) samples …”

Aspiration Cytology of Signet-Ring Cell Lymphoma

“…36 Although a rare entity, signetring cell lymphoma must also be considered in the differential diagnosis (Table I). Signet-ring cell lymphoma is an uncommon variant of follicular center cell lymphoma originally described by Kim et al 21 Sixty-seven cases subsequently appeared, [1][2][3][5][6][7][8][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][28][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] with only 4 diagnosed cytologic...…”

Signet Ring Adenocarcinoma Metastatic to the Bronchus and Mimicking Goblet Cell Hyperplasia

“…In addition, pathologists have recently identified signet ring variants of melanoma 36 and lymphoma 17,44 that cannot be distinguished from adenocarcinomas without ancillary studies. Some of these mimics have been successfully diagnosed on cytologic materials, including melanoma 33,41 and lymphoma 24,26,46,47 with signet ring cell morphology. Also, there are numerous nonneoplastic mimics of adenocarcinoma, including signet ring sinus histiocytosis 13,19 and artifactual signet ring cells in association with gastric lymphoma.…”