Significance of a Feeding Test with Check of Serum-Gastrin in Man and Dog

Holle, F; Bauer, H.; Becker, H. D.; Reeder, David D.; Thompson, James C.

doi:10.1007/978-3-642-65889-1_15

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Bone et aL (3) also found in their dogs that there was no change in fasting plasma IRG after PCV. On the contrary many authors reported an increase in fasting plasma IRG after truncal, selective or highly selective gastric vagotomy (5,10,14,19). Some species difference may exist.…”

Section: Discussionmentioning

confidence: 98%

Parietal Cell Vagotomy in Dogs

Boiselle¹,

Rozé²,

Vatier³

1978

Digestion

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The aim of this work was to further investigate whether it is possible, through parietal cell vagotomy (PCV), to obtain both a complete suppression of the gastric secretory response to vagal impulses and to retain a normal contractile response of the antral muscle. Acid and peptic secretions, the electrical activity and the force of circular antral contractions were simultaneously studied in dogs, before and after PCV, under 2-deoxy-D-glucose (2DG) and pentagastrin (PG) stimulation. After PCV, the response to 200 mg/kg 2DG was reduced by about 70% for acid and 80% for pepsin; the slopes of the dose-response curves were significantly reduced after PCV. The slope of the regression line pepsin/acid after 2DG was decreased following PCV. The mean acid response to PG was reduced about 50% after PCV. Plasma immunoreactive gastrin increased following 2DG, and the variations were identical before and after PCV. The gastric control electrical activity in basal conditions (fasted dogs) and following 2DG was similar before and after PCV. The antral contractile response to 2DG was reduced by about 40% after PCV. In conclusion, when PCV induced an 80% reduction in the gastric secretory response to maximal vagal stimulation by 2DG, the contractile antral response was not entirely normal. This effect might be due either to a partial antral denervation or to some intrinsic influence of the denervated gastric body upon the strength of antral contractions.

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Section: Discussionmentioning

confidence: 98%

Parietal Cell Vagotomy in Dogs

Boiselle¹,

Rozé²,

Vatier³

1978

Digestion

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“…The IRG response to a test meal increased significantly following SPV for at least two reasons. Our previous studies showed that a test meal emptied slower after SPV [9,10], and thereby could have caused a greater and more prolonged release ofgastrin. It is evident from Figures 2 and 3 that this is one likely explanation since a subsequent pyloroplasty caused a significant reduction of the IRG response to the test meal.…”

Section: Discussionmentioning

confidence: 99%

The effect of selective proximal vagotomy with and without pyloroplasty on serum gastrin levels and acid secretion after feeding and sham feeding in dogs

et al. 1977

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In a first operative stage, 4 dogs were prepared with Heidenhain pouches (HP) and 3 with Pavlov pouches (PP), 2 of the latter with an additional esophageal cannula. In a second stage all dogs had a selective proximal vagotomy (SPV), and in a third stage a submucosal pyloroplasty (P). Sham feeding experiments were carried out on the 2 dogs with PP and an esophageal fistula before and after SPV. Feeding tests were performed in all animals after the three operative procedures. Gastrin release after sham feeding increased significantly after SPV, whereas PP acid secretion was abolished. Gastrin release after feeding increased significantly after SPV in both HP and PP dogs. Acid secretion from HP was correlated with the changes in postprandial serum gastrin levels. PP acid secretion was diminished after SPV, in spite of the elevated gastrin levels. Subsequent pyloroplasty induced a significant decrease in the postprandial gastrin levels in both HP and PP dogs. However, acid secretion decreased significantly only in HP dogs.

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Significance of a Feeding Test with Check of Serum-Gastrin in Man and Dog

Cited by 2 publications

References 12 publications

Parietal Cell Vagotomy in Dogs

Parietal Cell Vagotomy in Dogs

The effect of selective proximal vagotomy with and without pyloroplasty on serum gastrin levels and acid secretion after feeding and sham feeding in dogs

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