Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder

Improved diagnostic precision of urine cytology by implementation of The Paris System and the use of cell blocks

“…The clinical behavior and management of lesions with focal high grade in the background of LGUC are not well established. 17 Our study was limited by its retrospective nature as well as selection bias. It included only cases in which there was a subsequent histologic specimen and also consisted predominantly of instrumented specimens; therefore, our percentages do not reflect the entire population of patients undergoing urine cytology testing.…”

“…We note that the surgical biopsy for these cases also demonstrated only focal high grade in a background of LGUC. The clinical behavior and management of lesions with focal high grade in the background of LGUC are not well established …”

Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway

“…Three recent publications have suggested that urothelial carcinomas with grade heterogeneity have a prognosis more in keeping with low‐grade carcinomas based on time to recurrence and disease‐free survival. However, previous literature has suggested that molecular markers may predict tumour behaviour more accurately than conventional histology .…”

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR)

“…There is some evidence that tumours with a limited amount of high‐grade component have improved outcome compared with those cases that are purely or predominantly high‐grade. For example, some authors recommended considering a tumour as low‐grade if the high‐grade component accounted for less than 5% of tumour volume . Stage progression was no higher in such mixed cases with <5% high grade tumour, compared with pure low‐grade tumours in the series by Reis et al .…”

“…For example, some authors recommended considering a tumour as low‐grade if the high‐grade component accounted for less than 5% of tumour volume . Stage progression was no higher in such mixed cases with <5% high grade tumour, compared with pure low‐grade tumours in the series by Reis et al . Using 1999 WHO grading of bladder tumours, Billis et al found that pure grade 3 tumours are more often muscle invasive than tumours with mixed grades 2 and 3, although percentages of grades in the mixed cases were not provided .…”