“…We were, however, unable to demonstrate that a longer duration of symptoms before an attempted enema reduction at the CH, with or without a prior attempt at a referring hospital, correlated with a significantly lower success rate or a greater incidence of complications. This finding is supported by other studies [14][15][16], although most authors have reported a negative impact of prolonged symptoms on outcome [6,[17][18][19][20][21][22]. If a longer duration of symptoms did have an effect on outcome that we were unable to detect because of a type-2 error, it would not likely have influenced our primary conclusion regarding repeat enema reduction in transferred patients because the symptom duration was comparable in the subjects who were transferred compared with those primarily managed at the CH.…”