Palmer amaranth (Amaranthus palmeri S. Watson) resistant to post-emergence (POST) applications of photosystem (PS) II-and 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicides has been confirmed in a continuous corn (Zea mays L.) seed production field in Nebraska. Field studies were conducted in 2014 through 2016 near Shickley in Fillmore County, Nebraska, to determine the response of Palmer amaranth to PS II-and HPPD-inhibiting herbicides applied pre-emergence (PRE) and to their tank-mixtures applied PRE or POST. Results from the dose-response study indicated that atrazine at 3757 and 17,920 g a.i. ha-1 applied PRE provided 25 and 45% Palmer amaranth control, respectively, at 28 d after treatment (DAT). Mesotrione and isoxaflutole doses required for 90% control were 1030 and 1140 g ha-1 , respectively. To determine the interactions of mesotrione, tembotrione, or topramezone tank-mixed with atrazine applied POST, Colby's equation was used to calculate the expected Palmer amaranth control achieved with those tank-mixtures compared to a nontreated control. Based on Colby's equation, additive interactions occurred for Palmer amaranth control, density reduction, and biomass reduction when atrazine tank-mixed with mesotrione or isoxaflutole was applied PRE at all rate combinations. However, synergistic interactions occurred when mesotrione or topramezone tank-mixed with atrazine was applied POST. The results indicated that Palmer amaranth from Nebraska is resistant to both PS II-and HPPD-inhibiting herbicides applied PRE or POST alone; however, they can be applied POST in a tank-mixture with different site of action herbicides for effective control and to reduce the risk of herbicide resistance evolution.