Significance of B-catenin Immunohistochemical Expression in Colorectal Carcinoma

Abstract

Background and objectives: Colorectal cancer is the third leading cause of cancer death worldwide and B- catenin has a role in the development of colorectal cancer. The objective of this study was to investigate the B-catenin expression of colorectal carcinoma and assess its correlation with some clinicopathological parameters in Erbil, Kurdistan of Iraq. Methods: Retrospective study of 100 patients with colorectal cancer collected between January 2015 and January 2017. Clinicopathological parameters were investigated in relation to nuclear and cytoplasmic B-catenin expression. Results: In 100 specimens of colorectal carcinomas was found to be nuclear (21.6%) and cytoplasm (66.1%). B-catenin was expressed more frequently in patients? 50 years (67.9%), and more commonly in females (60.7%). Left side colon was more frequently affected (85.7%) than the right side (14.3%) with a signifi- cant correlation. Well to moderately differentiated tumors showed higher intensity (89.3%) than poorly differentiated cases (10.7%). Non-mucinous tumors (92.9%) stained more intensely than mucinous tumor (7.1%). 52% of tumor cells were grade I, 37% grade II and 11% grade III. The result of association for B-catenin combined nuclear and cyto- plasmic with intensity of nuclear staining was highly significant. Higher staining intensity is observed in patients with positive nodal status (60.7%) and stage III-IV (60.7%) than those of stage I-II (39.3%). Conlision: B-catenin was studied in 100 specimens of colorectal cancers, with nuclear staining observed in (21.6%) and cytoplasmic reactivity in (66.1%). Significance was found between intensity of immunoexpression and cellular localization of B-catenin, as well as with clinical parameters of increasing age, female gender, and left sided colonic tumors on another hand