Significance of Body Mass Index in the Classification of PCOS: A Comparative Study in Northeast India

Pillai, Swapna S; Phukan, Pranay K; Dihingia, Prasanta

doi:10.5005/jp-journals-10006-1776

Journal of South Asian Federation of Obstetrics and Gynaecology

2020

DOI: 10.5005/jp-journals-10006-1776

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Significance of Body Mass Index in the Classification of PCOS: A Comparative Study in Northeast India

Swapna S Pillai¹,

Pranay K Phukan²,

Prasanta Dihingia³

Abstract: Aim: To compare the clinical and biochemical characteristics of obese and lean women with polycystic ovary syndrome (PCOS). To confirm the significance of body mass index (BMI) in classifying PCOS.

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Cited by 2 publications

References 18 publications

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Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study

Singh,

Kaur,

Beri

et al. 2023

Sci Rep

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This study was conducted to analyze the association of Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) gene rs4953616 and rs7371084 polymorphisms with the risk of polycystic ovary syndrome (PCOS) in Punjab, India. A total of 823 women (443 PCOS cases and 380 healthy controls) were enrolled in the present study. The polymerase chain reaction-restriction fragment length polymorphism technique (PCR–RFLP) was used for genotyping. Anthropometric parameters, lipid and hormonal profiles, were compared between the two groups. Demographic features were compared using Mann Whitney U test while the Chi-square test and odds ratios (ORs) were used to assess the genetic association and risk towards PCOS, respectively. A one-way analysis of variance (ANOVA) test was employed to analyze the correlation of genotypes with baseline parameters in PCOS cases. A statistically significant difference was revealed in the genotypic and allelic frequencies of rs4953616 polymorphism between PCOS cases and controls (p = 0.01 and p = 0.004, respectively). The mutant genotype (TT), mutant allele (T), and recessive model of rs4953616 polymorphism conferred 1.77, 1.3, and 1.5 times risk towards PCOS, respectively. No significant distribution for genotypes and alleles was found for rs7371084 in both groups (p = 0.25 and p = 0.26, respectively). In addition to dyslipidemia, PCOS women also had significantly higher body mass index (BMI) and waist-to-hip ratio (WHR), testosterone (T), and luteinizing hormone (LH). Upon haplotype analysis, the TT haplotype was found to be significantly associated with the increased risk of PCOS. Our results demonstrated a significant role of LHCGR rs4953616 polymorphism in the development of PCOS.

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Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study

Singh,

Kaur,

Beri

et al. 2023

Sci Rep

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Clinicobiochemical Analysis of Polycystic Ovary Syndrome and Metabolic Syndrome: Do They Go “Hand in Glove”?

Mishra¹,

Mishra²

2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Significance of Body Mass Index in the Classification of PCOS: A Comparative Study in Northeast India

Abstract: Aim: To compare the clinical and biochemical characteristics of obese and lean women with polycystic ovary syndrome (PCOS). To confirm the significance of body mass index (BMI) in classifying PCOS.

Cited by 2 publications

References 18 publications

Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study

Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study

Clinicobiochemical Analysis of Polycystic Ovary Syndrome and Metabolic Syndrome: Do They Go “Hand in Glove”?

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