Significance of C-reactive protein in osteoarthritis and total knee arthroplasty outcomes

Smith, Jessica; Martins, Thomas B.; Gopez, Evelyn V.; Johnson, Troy D.; Hill, Harry R.; Rosenberg, Thomas

doi:10.1177/1759720x12455959

Cited by 40 publications

(36 citation statements)

References 24 publications

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“…Those with positive CRP results had greater chance to acquire knee OA in contrast to negative CRP findings which had a protective effect. This is in accordance with the three studies done in USA [20][21][22] where they found a correlation between patients with elevated CRP and the presence of inflammatory changes in patients with KOA. They illustrated that the elevated CRP levels seen in these patients might reflect local inflammation within the joint and Interleukin 6(IL-6) is known to be the chief regulator of CRP production and may have a role in the inflammatory OA process.…”

Section: Methodssupporting

confidence: 92%

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Pirdawood¹,

Albarzinji

2017

ZJMS

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Section: Methodssupporting

confidence: 92%

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Pirdawood¹,

Albarzinji

2017

ZJMS

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“…Previous studies showed that the elevation of serum CRP is associated with knee as well as hip osteoarthritis prediction and severity if compared to healthy individuals [29], [30]. Our results demonstrated significant decrease in CRP in US group compared to Lev group and LLLT group.…”

Section: Effects Of Ultrasound Versus Low Level Laser Therapy In Levosupporting

confidence: 60%

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Mahmoud¹,

Elbedewey²,

Abdelkader³

et al. 2017

IOSR JDMS

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Abstract:Objectives. Osteoarthritis (OA) Methods. Eighteen male rats divided into three groups; (Lev) group treated with levofloxacin (Lev), (US) group treated with Lev plus US and (LLLT) group treated with Lev plus low level laser therapy. All animals received total of 200 mg injection of Lev. Total of ten sessions of US and laser applied. Results. We found significant decrease of serum IL-1beta, Mankin's score and increase in knee extension angle in both US and LLLT groups compared to Lev group. US significantly lower IL-6, INF-gamma, CRP and significantly elevate IL-10 in US group compared to Lev and LLLT groups.Conclusion. Based on our finding, US may provide better therapeutic effect compared to LLLT in knee osteoarthritis as indicated by reduction of inflammatory cytokines, elevation of anti-inflammatory cytokines and better histopathological score.

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“…Elevated high sensitivity C reactive protein (hs-CRP) predicts cartilage loss associated with osteoarthritis, as well as poorer outcomes after total knee joint replacement 57 66 67. Similar effects have also been found for interleukin 6 (IL-6) 57 68.…”

Section: Potential Value Of Biomarkers In Osteoarthritismentioning

confidence: 78%

Republished: Value of biomarkers in osteoarthritis: current status and perspectives

Lotz

Martel‐Pelletier

Christiansen

et al. 2014

Postgraduate Medical Journal

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Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the ‘omics’ (genomics, metabolomics, proteomics and lipidomics); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis.

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Significance of C-reactive protein in osteoarthritis and total knee arthroplasty outcomes

Abstract: The results of this study provide support for inflammatory mechanisms contributing to the OA progression, with hs-CRP being a possible predictive variable, combined with BMI and other comorbidities, of post-TKA function.

Cited by 40 publications

References 24 publications

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Republished: Value of biomarkers in osteoarthritis: current status and perspectives

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