Significance of Candida recovered from intraoperative specimens in patients with intra-abdominal perforations

Abstract

Single-dose intraoperative fluconazole prophylaxis did not have a statistically significant effect on overall mortality (odds ratio = 0.21; 95% confidence interval, 0.04-1.06; p = .059) in patients with intra-abdominal perforation. The recovery rate of yeast from intraoperative specimens from the abdominal cavity was high (>30%) and was associated with death and a complicated postoperative course.

Mannose-Binding Lectin Deficiency Facilitates AbdominalCandidaInfections in Patients with Secondary Peritonitis

“…Abdominal yeast infections were encountered with an incidence comparable to those reported in previous studies of secondary peritonitis (10,12,38). A significantly higher proportion of MBL variant patients had an early AYI (at index laparotomy) than WT patients.…”

“…When Candida species are recovered from abdominal isolates from cases of peritonitis, mortality is 60 to 70% when untreated (32). Up to 40% of peritonitis patients have positive abdominal yeast cultures (10,12,38), and depending on the body site, Candida species are among the most commonly cultured microorganisms in surgical infections (39). In a recent study, the intraoperative detection of yeast was one of the few independent risk factors for mortality and increased morbidity in cases of secondary peritonitis (38).…”

“…Up to 40% of peritonitis patients have positive abdominal yeast cultures (10,12,38), and depending on the body site, Candida species are among the most commonly cultured microorganisms in surgical infections (39). In a recent study, the intraoperative detection of yeast was one of the few independent risk factors for mortality and increased morbidity in cases of secondary peritonitis (38). Yeast is the fourth leading cause of all nosocomial bloodstream infections in the United States, taking third place in bloodstream infections in ICUs (46).…”

Detection of (1→3)-β- d -Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation

“…There is no real consensus on the diagnostic criteria for fungal peritonitis, but in gastrointestinal surgery patients with anastomotic leakage, the isolation of fungi in tissue obtained in a surgical procedure establishes a sound diagnosis, as is the case for this patient (13).…”

Incidence and Significance of Intra-Operative Peritoneal Fluid Fungal Culture in Patients of Perforated Peptic Ulcers

“…Factors foretelling outcome in cases of perforation peritonitis are well known and have been well acknowledged in the construction of various scoring systems. (1,2) Increasing awareness of worse outcome after fungalco-infection, (3,4,5) and the knowledge that intra-abdominal microbialogical findings do not correlate with severity of illness as judged by the scoring systems, impelled usto conduct this study.…”