Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight

Javed, Rabia; Sajjad, Anila; Naz, Sania; Sajjad, Humna; Ao, Qiang

doi:10.3390/ijms231810521

Cited by 34 publications

(22 citation statements)

References 216 publications

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“…Capping agents used as reducing and stabilizing agents are mostly added along with precursors at the start of reaction during chemical fabrication of different nanoparticles (Javed et al 2020 , 2022b ). For instance, in an investigation, CuO NPs were fabricated using copper sulfate salt as precursor and aniline as capping agent (Rostami-Tapeh-Esmaeil et al 2021 ).…”

Section: Synthesis Techniquesmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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Versatile nature of copper oxide nanoparticles (CuO NPs) has made them an imperative nanomaterial being employed in nanomedicine. Various physical, chemical, and biological methodologies are in use for the preparation of CuO NPs. The physicochemical and biological properties of CuO NPs are primarily affected by their method of fabrication; therefore, selectivity of a synthetic technique is immensely important that makes these NPs appropriate for a specific biomedical application. The deliberate use of CuO NPs in biomedicine questions their biocompatible nature. For this reason, the present review has been designed to focus on the approaches employed for the synthesis of CuO NPs; their biomedical applications highlighting antimicrobial, anticancer, and antioxidant studies; and most importantly, the in vitro and in vivo toxicity associated with these NPs. This comprehensive overview of CuO NPs is unique and novel as it emphasizes on biomedical applications of CuO NPs along with its toxicological assessments which would be useful in providing core knowledge to researchers working in these domains for planning and conducting futuristic studies. Key Points • The recent methods for fabrication of CuO nanoparticles have been discussed with emphasis on green synthesis methods for different biomedical approaches. • Antibacterial, antioxidant, anticancer, antiparasitic, antidiabetic, and antiviral properties of CuO nanoparticles have been explained. • In vitro and in vivo toxicological studies of CuO nanoparticles exploited along with their respective mechanisms. Graphical Abstract

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Section: Synthesis Techniquesmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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“…From a mechanistic point of view, capping agents act as barriers or coatings that, due to their cationic or anionic nature, can produce electrostatic interactions between particles during their formation and, thus, prevent their aggregation. This is also avoided due to the stearic hindrance caused by the length of polymeric or amino acidic capping agents [166,167]. Examples and functions of capping agents are represented in Figure 4.…”

Section: Capping Agentsmentioning

confidence: 99%

Activities against Lung Cancer of Biosynthesized Silver Nanoparticles: A Review

2023

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Nanomedicine is an interdisciplinary field where nanostructured objects are applied to treat or diagnose disease. Nanoparticles (NPs) are a special class of materials at nanometric scale that can be prepared from lipids, polymers, or noble metals through bottom-up approaches. Biological synthesis is a reliable, sustainable, and non-toxic bottom-up method that uses phytochemicals, microorganisms, and enzymes to induce the reduction of metal ions into NPs. Silver (Ag) NPs exhibit potent therapeutic properties that can be exploited to overcome the limitations of current treatment modalities for human health issues such as lung cancer (LC). Here, we review the preparation of AgNPs using biological synthesis and their application against LC using in vitro and in vivo models. An overview of the staging, diagnosis, genetic mutations, and treatment of LC, as well as its main subtypes, is presented. A summary of the reaction mechanisms of AgNPs using microbial cell cultures, plant extracts, phytochemicals, and amino acids is included. The use of capping agents in the biosynthesis of AgNPs with anticancer activity is also detailed. The history and biological activities of metal-based nanostructures synthesized with gold, copper, palladium, and platinum are considered. The possible anticancer mechanisms of AgNPs against LC models are covered. Our perspective about the future of AgNPs in LC treatment and nanomedicine is added.

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“…Capping agents are molecules that play an essential role in the growth, aggregation, and physicochemical properties of nanoparticles by regulating their size, shape, geometry, and surface chemistry ( Javed et al, 2022 ; Sidhu et al, 2022 ). Capping agents can firmly adsorb on the nanoparticle surface forming a single or multilayer protective coating thus providing long term nanoparticle stability ( Javed et al, 2022 ). Capping agents can consist of proteins, carbohydrates, amino acids, and lipids ( Bulgarini et al, 2021 ) and can prevent aggregation of nanoparticles ( Sidhu et al, 2022 ).…”

Section: Toxicity Of Nanoparticles and The Role Of Capping Agentsmentioning

confidence: 99%

“…Capping agents are found in biological organisms, and they can act as reducing and stability agents, an advantage that is noteworthy for biogenic nanoparticles ( Guilger-Casagrande et al, 2021 ), ( Javed et al, 2022 ). In addition, capping agents from biological organisms can be introduced to the chemical synthetic strategies and this has become an essential strategy in lowering the cytotoxic effects of chemically synthesized nanoparticles ( Sidhu et al, 2022 ).…”

Section: Toxicity Of Nanoparticles and The Role Of Capping Agentsmentioning

confidence: 99%

Biogenic metallic nanoparticles as enzyme mimicking agents

Ngcongco

Krishna²,

Pillay³

2023

Front. Chem.

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The use of biological systems such as plants, bacteria, and fungi for the synthesis of nanomaterials has emerged to fill the gap in the development of sustainable methods that are non-toxic, pollution-free, environmentally friendly, and economical for synthesizing nanomaterials with potential in biomedicine, biotechnology, environmental science, and engineering. Current research focuses on understanding the characteristics of biogenic nanoparticles as these will form the basis for the biosynthesis of nanoparticles with multiple functions due to the physicochemical properties they possess. This review briefly describes the intrinsic enzymatic mimetic activity of biogenic metallic nanoparticles, the cytotoxic effects of nanoparticles due to their physicochemical properties and the use of capping agents, molecules acting as reducing and stability agents and which aid to alleviate toxicity. The review also summarizes recent green synthetic strategies for metallic nanoparticles.

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Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight

Cited by 34 publications

References 216 publications

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Activities against Lung Cancer of Biosynthesized Silver Nanoparticles: A Review

Biogenic metallic nanoparticles as enzyme mimicking agents

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