Significance of cardiac troponin T release after percutaneous transluminal coronary angioplasty

Karim, M.Asad; Shinn, Marlene; Oskarsson, Helgi; Windle, John R.; Deligönül, Ubeydullah

doi:10.1016/s0002-9149(99)80144-1

Cited by 70 publications

(37 citation statements)

References 8 publications

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“…Various results with respect to the incidence of TnT release after elective coronary angioplasty have been reported. [16][17][18][19] The incidence of TnT release exceeding the cut-off point in the control group of our study was 42%, which is similar to that (44%) reported by Karim, et al 16) but higher than those (13% and 8.9%, respectively) reported by Shyu, et al 17) and Ohnishi, et al 19) The difference in the incidence of TnT release may be due to the difference in the total balloon inflation time during angioplasty. 18) Intracoronary pressure-derived CFI has often been used for evaluating coronary collateral function during coronary angioplasty.…”

Section: Discussionsupporting

confidence: 84%

“…15) Several studies have shown that TnT elevation is observed in some patients undergoing elective coronary angioplasty, indicating that the elevation reflects minor myocardial damage. [16][17][18][19] Moreover, TnT has been shown to be more sensitive and specific than creatine kinase-MB for the detection of myocardial damage after angioplasty. 16,17) The aim of the present study was to examine the preconditioning effect of nicorandil on TnT release after coronary angioplasty in patients with stable angina pectoris.…”

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confidence: 99%

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Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

et al. 2002

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SUMMARYNicorandil has been reported to have a preconditioning effect which suppresses the ST-segment shift or lactate production during coronary angioplasty in patients with stable angina pectoris. The present study investigated whether the preconditioning effect of nicorandil affects troponin T (TnT) levels after coronary angioplasty. Twenty-four patients with stable angina pectoris were randomized to receive a 1-minute intravenous infusion of nicorandil (100 µg/kg) or normal saline. Five minutes later they underwent three 2-minute balloon inflations 5 minutes apart. The sum of ST-segment elevation in all leads (∑ST) was determined at the end of each balloon inflation. Serum levels of TnT were measured 6 and 18 hours after the procedure, and the higher value of the two measurements was compared between the groups. ∑ST decreased progressively during the three sequential balloon inflations in both groups and was less in the nicorandil group than in the control group. The TnT level after the procedure was significantly lower in the nicorandil group than in the control group (0.05±0.05 vs 0.11±0.10 ng/mL). In conclusion, pretreatment with intravenous nicorandil suppresses TnT release after coronary angioplasty as well as ST-segment elevation during coronary angioplasty, suggesting pharmacological preconditioning by nicorandil. (Jpn Heart J 2002; 43: 443-453)

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Section: Discussionsupporting

confidence: 84%

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confidence: 99%

Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

et al. 2002

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“…6 Several reports have shown that an increase in cardiac troponin T can be found in a proportion of patients after PCI ranging from less than 10% to almost 50%. 2,3 The proportion of elevation of troponin T after PCI in our study was 33.5% (70/209). This supports that cardiac troponin T elevation was quite common after PCI in patients with stable CAD.…”

Section: Discussionmentioning

confidence: 51%

“…Several reports have shown that an increase in cardiac troponin T can be found in a proportion of patients after percutaneous coronary intervention (PCI), ranging from less than 10% to almost 50%. 2,3 It has also been reported that elevation of troponin T is relatively common among patients with stable coronary artery disease undergoing PCI and is an independent prognostic indicator of ischemic complications. 4,5 However, there were few studies about comprehensive risk factor analysis of troponin T elevation in patients with stable CAD after drug-eluting stent (DES) implantation.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Cardiac Troponin T Elevation in Patients with Stable Coronary Artery Disease After Elective Coronary Drug‐Eluting Stent Implantation

Chen

Qian

et al. 2011

Clinical Cardiology

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Background: Cardiac troponin T elevation after coronary intervention has been demonstrated to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug-eluting stent (DES) implantation. Hypothesis: The prognosis of CAD after coronary interventions was associated with clinical and procedural risk factors of CAD, such as age, hypertension, severity extent of CAD and so on. Methods: From March to December in 2010, patients with stable CAD were admitted for elective coronary intervention in our hospital. They were divided into an elevated troponin T group and a normal troponin T group by postprocedural troponin T. Clinical factors, laboratory-test factors, and angiographic factors (such as gender, age, cholesterol, Gensini score, and others) were analyzed. Results: A total of 209 patients with an average age of 64.0 ± 9.9 years were enrolled in the study: 70 patients with elevated troponin T (≥0.03 ng/mL) after DES implantation and 139 patients with normal troponin T (<0.03 ng/mL). After univariate analysis, we found that age, hypertension, total cholesterol, low density lipoprotein-cholesterol (LDL-C), Gensini score, number of stenosed vessels, and total implanted stents were associated with postprocedural troponin T elevation. According to the results of multivariate analysis, we found that age, total cholesterol, number of stenosed vessels, and number of implanted stents were independent risk factors of postprocedural troponin T elevation. Conclusions: Age, serum total cholesterol, number of stenosed vessels, and number of implanted stents could be independent risk factors of troponin T elevation after elective DES implantation.

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“…The concentration returns to normal range after 5-14 days. The cTnT is very cardiac specific, and it is not present in the serum following nonmyocardial muscle or other tissue damage 18) . Cardiac troponin elevations have been reported in numerous conditions such as sepsis, pulmonary embolism, pericarditis, chronic renal failure, major trauma, stroke and SAH 3,14,19) .…”

Section: Discussionmentioning

confidence: 99%

Initial Troponin Level as a Predictor of Prognosis in Patients with Intracerebral Hemorrhage

Chung

Won

Kwon

et al. 2009

J Korean Neurosurg Soc

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Objective : It has been suggested that elevated cardiac troponin T (cTnT) level is a marker of increased risk of mortality in acute ischemic stroke and subarachnoid hemorrhage (SAH). However, the association of serum cTnT level and prognosis of intracerebral hemorrhage (ICH) has been sparsely investigated. The aim of this study was to identify the relationship between cTnT level and the outcome in patients with spontaneous ICH. Methods : We retrospectively investigated 253 patients identified by a database search from records of patients admitted in our department for ICH between January 1, 2003 and December 31, 2007. The patients were divided into 2 groups; the patients in group 1 (n=225) with serum cTnT values of 0.01 ng/mL or less, and those in group 2 (n=28) with serum cTnT values greater than 0.01 ng/mL. Results : The serum cTnT level was elevated in 28 patients. There were significant differences in sex, hypertension, creatine kinase-myocardial band, midline shift, side of hematoma, and presence of intraventricular hemorrhage between the 2 groups. Logistic regression analysis identified the level of consciousness on admission, cTnT and midline shift as independent predictors of hospital mortality. Conclusion : Theses results suggest that increased serum cTnT level at admission is associated with in-hospital mortality and the addition of a serum cTnT assay to routine admission testing should be considered in patients with ICH.

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Significance of cardiac troponin T release after percutaneous transluminal coronary angioplasty

Cited by 70 publications

References 8 publications

Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

Risk Factors of Cardiac Troponin T Elevation in Patients with Stable Coronary Artery Disease After Elective Coronary Drug‐Eluting Stent Implantation

Initial Troponin Level as a Predictor of Prognosis in Patients with Intracerebral Hemorrhage

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