Significance of Cerebellar Atrophy in Intractable Temporal Lobe Epilepsy: A Quantitative MRI Study

Sandok, Evan K.; O’Brien, Terence J.; Jack, Clifford R.; So, Elson L.

doi:10.1111/j.1528-1157.2000.tb04611.x

Cited by 87 publications

(66 citation statements)

References 27 publications

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“…Finally, we did not examine all the potential subcortical structures that may be affected in unilateral TLE. For example, there are reports of cerebellar volume loss in TLE patients [41].…”

Section: Limitationsmentioning

confidence: 99%

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

Pulsipher

Seidenberg

Morton

et al. 2007

Epilepsy & Behavior

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Few studies have examined the relative degree of brain volume loss in both the hippocampi and subcortical structures in unilateral temporal lobe epilepsy (TLE), and their association with clinical seizure correlates. In this study, quantitative MRI volumes were measured in the hippocampus, thalamus, caudate, putamen, and corpus callosum in 48 unilateral TLE patients (26 rights, and 22 lefts) and compared to 29 healthy controls. The ipsilateral hippocampus, corpus callosum, and bilateral thalami showed the greatest volume loss, reflected by large to moderate effect size differences compared to controls. Bilaterally, the putamen showed the next highest volume reduction. The contralateral hippocampus and bilateral caudate nuclei showed the least volume reduction, characterized by small effect sizes. Furthermore, clinical seizure characteristics (e.g, duration of epilepsy) showed different patterns of association with the volume reductions observed across these structures. Findings suggest that distinct neurodevelopmental features may play a role in the volume abnormality observed in these regions.

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“…Finally, we did not examine all the potential subcortical structures that may be affected in unilateral TLE. For example, there are reports of cerebellar volume loss in TLE patients [41].…”

Section: Limitationsmentioning

confidence: 99%

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

Pulsipher

Seidenberg

Morton

et al. 2007

Epilepsy & Behavior

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“…Failure to correct for f1 can lead to spuriously low control binding, by underestimating the relative amount of tracer availability (7,37,43). Moreover, correction for non-specific binding using cerebellum could lead to inaccuracies due to the cerebellar atrophy that occurs in epilepsy, as well as spill-over of [ 18 F]fluoride activity from adjacent skull, corrections for acid metabolite entering the brain, atrophy due to epilepsy or AEDs, or cerebellar binding heterogeneity (7,41,44). Moreover, cerebellar and occipital V, presumably representing non-specific binding, was very low (increasing the risk of measurement inaccuracy), and there were no significant differences in cerebellar or occipital V/f 1 between patients with or without MDD.…”

Section: Statistical Analysesmentioning

confidence: 99%

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Hasler

Bonwetsch

Giovacchini

et al. 2007

Biological Psychiatry

129

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Background-Major depressive disorder (MDD) is the most common comorbid psychiatric condition associated with temporal lobe epilepsy (TLE). Preclinical and clinical studies suggest that 5-HT 1A receptors play a role in the pathophysiology of both TLE and MDD. There is preliminary evidence for an association between decreased 5-HT 1A receptor binding in limbic brain areas and affective symptoms in TLE patients. The objective of this study was to compare 5-HT 1A receptor binding between TLE patients with and without MDD. For the first time, 5-HT 1A receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews.

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“…41 One study comparing cerebellar volume and head circumference supports this research by reporting a positive correlation. 39 Varying degrees of cerebellar atrophy have been determined in studies involving individuals with attention deficit hyperactivity disorder, 29,43 autism, 23,30 cleft palate or cleft lip, 31 Down syndrome, 20 cerebral palsy, 28 and epilepsy 26 . In the context of the findings in the literature, this study provides a database suitable for clinical use by measuring cerebellar dimension development in healthy individuals aged 0-4 years in order to for it to be possible for such anomalies to be identified in the early period.…”

Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22][23][24][25][26][27][28][29][30][31] The cerebellar dimensions obtained in the study will be useful in clinical practice by making it possible to assess a decrease in cerebellum dimensions on radiological images between the ages of 0 and 4 years, when the cerebellum is still growing, and will also be applicable for the standardization of measurement values. The purpose of this study was therefore to obtain a database suitable for clinical use by performing cerebellar development dimension measurements in normal individuals aged 0-4 years.…”

Section: Assessment Of Cerebellar Dimensions Usingmentioning

confidence: 99%

Assessment of Cerebellar Dimensions Using Magnetic Resonance Imaging in Children Aged 0-4 Years

Ayhan¹,

Yeğinoğlu²,

Kul³

2015

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Several diseases progress with cerebellar atrophy and hypoplasia. Cerebellum dimension measurements facilitating the assessment of decreases in cerebellum size on radiological images between the ages of 0 and 4 years in particular, when the cerebellum is still growing, will be of considerable use in clinical practice and appropriate for measurement value standardization. This will allow easier interpretetation of findings, together with more accurate diagnosis or a decrease in delays caused by false diagnosis. This study, the purpose of which was to obtain a database suitable for clinical use by performing cerebellar development dimension measurements in normal individuals aged 0-4 years, investigated the effect on cerebellar dimensions of parameters such as height, weight, head circumference and birth week. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : One hundred fourty children aged 0-4 years, 56 girls and 84 boys, undergoing magnetic resonance imaging of the brain at the Karadeniz Technical University Farabi Hospital Radiology Department with no structural cerebral or cerebellar abnormalities were included in the study. R Re es su ul lt ts s: : In this study of cerebellar dimensions in healthy children, these were positively correlated with weight, head circumference and height in both genders. Preterm birth had a significant effect on cerebellar dimensions. C Co on nc cl lu us si io on n: : In conclusion, this scale developed by measuring the cerebellar dimensions of healthy children aged 0-4 years will be of considerable practical assistance in terms of assessing measurements performed in a clinical environment. K Ke ey y W Wo or rd ds s: : Magnetic resonance imaging; child Ö ÖZ ZE ET T A Am ma aç ç: : Serebellumun atrofisi ve hipoplazisi ile giden birçok hastalık mevcuttur. Özellikle serebellumun büyümeye devam ettiği 0-4 yaş arasında radyolojik görüntülerde serebellum boyutlarındaki azalmanın değerlendirilebilmesi için serebellum boyutlarının ölçümleri, klinikte pratik olarak yararlı olacak ve ölçüm değerlerinin standardizasyonu için uygun olacaktır. Böylece bulguların daha kolay tanımlanabileceği ve doğru tanı konulamaması ya da tanı konulmasındaki gecikmelerin azalacağı öngörülmektedir. Bu nedenle 0-4 yaş arası normal bireylerde serebellum gelişimi boyut ölçümleri ile yaparak klinik kullanıma uygun bir veri dökümü elde etmeyi amaçladığımız bu çalışmada boy, kilo, baş çevresi, doğum haftası gibi parametrelerin serebellum boyutları üzerine etkilerini de değerlendirdik. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştırmaya Karadeniz Teknik Üniversitesi Radyoloji Bölümünde beyin manyetik rezonans görüntülemesi yapılan ve serebral ve serebellum anomalisi olmayan 0-4 yaş arasındaki 56 kız, 84 erkek çocuk dahil edilmiştir. B Bu ul lg gu ul la ar r: : Sağlıklı ço-cuklarda serebellum boyutlarını saptadığımız bu çalışmada, serebellum boyutlarının her iki cinsiyette boy, kilo ve baş çevresi ile pozitif korelasyon olduğu ve erken do...

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Significance of Cerebellar Atrophy in Intractable Temporal Lobe Epilepsy: A Quantitative MRI Study

Cited by 87 publications

References 27 publications

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Assessment of Cerebellar Dimensions Using Magnetic Resonance Imaging in Children Aged 0-4 Years

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